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CD4 T cells play a central role in the protective immunity against\n                    <jats:italic>Chlamydia<\/jats:italic>\n                    female reproductive tract (FRT) infection, while B cells are thought to be dispensable for resolution of primary\n                    <jats:italic>Chlamydia<\/jats:italic>\n                    infection in mouse models. We recently reported an unexpected requirement of B cells in local\n                    <jats:italic>Chlamydia<\/jats:italic>\n                    \u2010specific CD4 T\u2010cell priming and bacterial containment within the FRT. Here, we sought to tackle the precise effector function of B cells during\n                    <jats:italic>Chlamydia<\/jats:italic>\n                    primary infection. Using mixed bone marrow chimeras that lack B\u2010cell\u2013dependent Ag presentation (\n                    <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/eji4692-math-0001.png\" xlink:title=\"urn:x-wiley:00142980:media:eji4692:eji4692-math-0001\"\/>\n                    ) or devoid of circulating antibodies (AID\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    \u00d7 \u03bcS\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ), we show that\n                    <jats:italic>Chlamydia<\/jats:italic>\n                    \u2010specific CD4 T\u2010cell expansion does not rely on Ag presentation by B cells. Importantly, we demonstrate that antibody, but not B\u2010cell\u2013dependent Ag presentation, is required for preventing systemic bacterial dissemination following\n                    <jats:italic>Chlamydia<\/jats:italic>\n                    FRT infection.\n                  <\/jats:p>","DOI":"10.1002\/eji.201948391","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T04:00:39Z","timestamp":1580961639000},"page":"676-684","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Antibody, but not B\u2010cell\u2013dependent antigen presentation, plays an essential role in preventing\n                    <i>Chlamydia<\/i>\n                    systemic dissemination in mice"],"prefix":"10.1002","volume":"50","author":[{"given":"Priyangi A.","family":"Malaviarachchi","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology University of Arkansas for Medical Sciences  Little Rock AR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.B.","family":"Mercado","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University of Arkansas for Medical Sciences  Little Rock AR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"McSorley","sequence":"additional","affiliation":[{"name":"Center for Comparative Medicine, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine University of California  Davis CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5526-8966","authenticated-orcid":false,"given":"Lin\u2010Xi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University of Arkansas for Medical Sciences  Little Rock AR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62182-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.13.80"},{"key":"e_1_2_7_4_1","volume-title":"Global health sector strategy on sexually transmitted infections 2016\u20132021","author":"World Health Organization","year":"2016"},{"key":"e_1_2_7_5_1","volume-title":"Sexually transmitted disease surveillance 2017","author":"Division of STD Prevention\u2010CDC","year":"2018"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.65.6.2175-2182.1997"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162445"},{"key":"e_1_2_7_8_1","first-page":"201711356","article-title":"Pathology after Chlamydia trachomatis infection is driven by nonprotective immune cells that are distinct from protective populations","volume":"376","author":"Lijek R. 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