{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:52:44Z","timestamp":1788562364284,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004489","name":"Mitacs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004489","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","award":["33617"],"award-info":[{"award-number":["33617"]}],"id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Disrupting or harnessing immune suppression is leading to new therapeutic avenues in a number of immune\u2010related diseases. Understanding the suppressive functions of regulatory T cells (Tregs) in different environments is therefore key. Parasitic worms are strong inducers of Tregs and previous research has suggested that parasite\u2010induced Tregs are stronger suppressors than na\u00efve Tregs. In strains susceptible to the intestinal worm\n                    <jats:italic>Heligmosomoides polygyrus<\/jats:italic>\n                    , like C57BL\/6 mice, it has been hypothesized that increased Treg suppression downregulates both Th1 and Th2 responses, leading to chronic infections and high worm burden. Here, we show that the suppressive capacity of Tregs is no different between cells from infected and\/or naive animals. In vitro suppression induced by CD4\n                    <jats:sup>+<\/jats:sup>\n                    CD25\n                    <jats:sup>+<\/jats:sup>\n                    Tregs (Peyers\u2019 Patches or the mesenteric lymph nodes), isolated early (day 7, tissue dwelling phase) or late (day 21, luminal phase) during infection was similar to that induced by cells from na\u00efve animals. Suppression was CTLA\u20104 dependent in Tregs from acute but not chronic infection or in Tregs from na\u00efve animals. This highlights the versatility of Tregs and the importance of extensive Treg characterization prior to potential in vivo manipulation of this cell type.\n                  <\/jats:p>","DOI":"10.1002\/eji.201948392","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T15:58:31Z","timestamp":1587398311000},"page":"1167-1173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Suppressive mechanisms by\n                    <i>Heligmosomoides polygyrus<\/i>\n                    \u2010induced Tregs in C57BL\/6 mice change over time and differ to that of na\u00efve mice"],"prefix":"10.1002","volume":"50","author":[{"given":"Joel","family":"Bowron","sequence":"first","affiliation":[{"name":"Faculty of Science Department of Biological Sciences University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupama","family":"Ariyaratne","sequence":"additional","affiliation":[{"name":"Faculty of Science Department of Biological Sciences University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayara de Cassia","family":"Luzzi","sequence":"additional","affiliation":[{"name":"Faculty of Science Department of Biological Sciences University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edina","family":"Szabo","sequence":"additional","affiliation":[{"name":"Faculty of Science Department of Biological Sciences University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8459-8462","authenticated-orcid":false,"given":"Constance A. M.","family":"Finney","sequence":"additional","affiliation":[{"name":"Faculty of Science Department of Biological Sciences University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636751"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00266-15"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042572"},{"key":"e_1_2_7_5_1","first-page":"1","article-title":"Low\u2010level regulatory T\u2010cell activity is essential for functional type\u20102 effector immunity to expel gastrointestinal helminths","volume":"9","author":"Smith K.","year":"2015","journal-title":"Mucosal Immunol."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2013.109"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.07.007"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.6.782"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.182.2.741"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024226"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4771"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.127"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01233-07"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0604341"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.2.303"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2006.00415.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(94)90071-X"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.2.183"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.7.4626"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2007.00947.x"},{"key":"e_1_2_7_21_1","unstructured":"Finney C. 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