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In order to determine the role of IL\u201017 in development of allergic asthma, we used IL\u201017A\/F double KO (IL\u201017A\/F KO) and WT mice with or without neutralization of IL\u201017 in an experimental allergic asthma model and analyzed airway hyperresponsiveness, lung inflammation, T helper cell polarization, and DCs influx and activation. We report that the absence of IL\u201017 reduced influx of DCs into lungs and lung draining LNs. Compared to WT mice, IL\u201017A\/F KO mice or WT mice after neutralization of IL\u201017A showed reduced airway hyperresponsiveness, eosinophilia, mucus hypersecretion, and IgE levels. DCs from draining LNs of allergen\u2010challenged IL\u201017A\/F KO mice showed a reduction in expression of migratory and costimulatory molecules CCR7, CCR2, MHC\u2010II, and CD40 compared to WT DCs. Moreover, in vivo stimulation of adoptively transferred antigen\u2010specific cells was attenuated in lung\u2010draining LNs in the absence of IL\u201017. Thus, we report that IL\u201017 enhances airway DC activation, migration, and function. Consequently, lack of IL\u201017 leads to reduced antigen\u2010specific T cell priming and impaired development of experimental allergic asthma.<\/jats:p>","DOI":"10.1002\/eji.201948409","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T16:13:25Z","timestamp":1583511205000},"page":"1019-1033","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["IL\u201017 regulates DC migration to the peribronchial LNs and allergen presentation in experimental allergic asthma"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4693-0081","authenticated-orcid":false,"given":"Adan Chari","family":"Jirmo","sequence":"first","affiliation":[{"name":"Department of Pediatric Pneumology Allergology and Neonatology, Hannover Medical School  Hannover Germany"},{"name":"Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH) Member of the German Center 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