{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:14:38Z","timestamp":1790727278905,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,3,8]],"date-time":"2020-03-08T00:00:00Z","timestamp":1583625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC1181_A02"],"award-info":[{"award-number":["CRC1181_A02"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Repeated inhalation of airborne conidia derived from the fungus\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    (\n                    <jats:italic>Af<\/jats:italic>\n                    ) can lead to a severe eosinophil\u2010dominated inflammatory condition of the lung termed allergic bronchopulmonary aspergillosis (ABPA). ABPA affects about 5 million individuals worldwide and the mechanisms regulating lung pathology in ABPA are poorly understood. Here, we used a mouse model of ABPA to investigate the role of eosinophils and T\u00a0cell\u2010derived IL\u20104\/IL\u201013 for induction of allergic lung inflammation. Selective deletion of IL\u20104\/IL\u201013 in T\u00a0cells blunted the\n                    <jats:italic>Af<\/jats:italic>\n                    \u2010induced lung eosinophilia and further resulted in lower expression of STAT6\u2010regulated chemokines and effector proteins such as Arginase 1, Relm\u2010\u03b1, Relm\u2010\u03b2, and Muc5a\/c. Eosinophil\u2010deficient \u0394dblGata mice showed lower IL\u20104 expression in the lung and the number of Th2 cells in the lung parenchyma was reduced. However, expression of the goblet cell markers Clca1 and Muc5a\/c, abundance of mucin\u2010positive cells, as well as weight gain of lungs were comparable between\n                    <jats:italic>Af<\/jats:italic>\n                    \u2010challenged \u0394dblGata and WT mice. Based on these results, we conclude that T\u00a0cell\u2010derived IL\u20104\/IL\u201013 is essential for\n                    <jats:italic>Af<\/jats:italic>\n                    \u2010induced lung eosinophilia and inflammation while eosinophils may play a more subtle immunomodulatory role and should not simply be regarded as pro\u2010inflammatory effector cells in ABPA.\n                  <\/jats:p>","DOI":"10.1002\/eji.201948411","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T10:58:35Z","timestamp":1582887515000},"page":"1044-1056","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Th2 cells promote eosinophil\u2010independent pathology in a murine model of allergic bronchopulmonary aspergillosis"],"prefix":"10.1002","volume":"50","author":[{"given":"Axel","family":"Dietschmann","sequence":"first","affiliation":[{"name":"Department of Infection Biology University Hospital Erlangen and Friedrich\u2010Alexander University (FAU) Erlangen\u2010Nuremberg  Erlangen 91054 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Schruefer","sequence":"additional","affiliation":[{"name":"Institute of Clinical Microbiology, Immuology and Hygiene University Hospital Erlangen and Friedrich\u2010Alexander University (FAU) Erlangen\u2010Nuremberg  Erlangen 91054 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Krappmann","sequence":"additional","affiliation":[{"name":"Institute of Clinical Microbiology, Immuology and Hygiene University Hospital Erlangen and Friedrich\u2010Alexander University (FAU) Erlangen\u2010Nuremberg  Erlangen 91054 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6650-0639","authenticated-orcid":false,"given":"David","family":"Voehringer","sequence":"additional","affiliation":[{"name":"Department of Infection 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