{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:11:00Z","timestamp":1773659460957,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T00:00:00Z","timestamp":1592956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K99 AI139445"],"award-info":[{"award-number":["K99 AI139445"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009659","name":"Guangzhou Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["N_HKU737\/18"],"award-info":[{"award-number":["N_HKU737\/18"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Vaccine development against SARS\u2010CoV\u20102 has drawn attention around the globe due to the exploding pandemic. Although COVID\u201019 is caused by a new coronavirus, SARS\u2010CoV\u20102, previous research on other coronavirus vaccines, such as FIPV, SARS, and MERS, has provided valuable information for the rapid development of COVID\u201019 vaccine. However, important knowledge gaps remain \u2014 some are specific to SARS\u2010CoV\u20102, others are fundamental to immunology and vaccinology. Here, we discuss areas that need to be addressed for COVID\u201019 vaccine development, and what can be learned from examples of vaccine development in the past. Since the beginning of the outbreak, the research progress on COVID\u201019 has been remarkable. We are therefore optimistic about the rapid development of COVID\u201019 vaccine.<\/jats:p>","DOI":"10.1002\/eji.202048663","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T12:00:33Z","timestamp":1590062433000},"page":"939-943","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["COVID\u201019 vaccines: Knowing the unknown"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2218-0076","authenticated-orcid":false,"given":"Huibin","family":"Lv","sequence":"first","affiliation":[{"name":"HKU\u2010Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine The University of Hong Kong  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9078-6697","authenticated-orcid":false,"given":"Nicholas C.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Integrative Structural and Computational Biology The Scripps Research Institute  La Jolla CA 92037 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0525-6772","authenticated-orcid":false,"given":"Chris K. 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