{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:04:00Z","timestamp":1791497040703,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    B lymphocytes are among the cell types whose effector functions are modulated by mast cells (MCs). The B\/MC crosstalk emerged in several pathological settings, notably the colon of inflammatory bowel disease (IBD) patients is a privileged site in which MCs and IgA\n                    <jats:sup>+<\/jats:sup>\n                    cells physically interact. Herein, by inducing conditional depletion of MCs in red MC and basophil (RMB) mice, we show that MCs control B cell distribution in the gut and IgA serum levels. Moreover, in dextran sulfate sodium (DSS)\u2010treated RMB mice, the presence of MCs is fundamental for the enlargement of the IgA\n                    <jats:sup>+<\/jats:sup>\n                    population in the bowel and the increase of systemic IgA production. Since both conventional B\u20102 and peritoneal\u2010derived B cells populate the intestine and communicate with MCs in physiological conditions and during inflammation, we further explored this interplay through the use of co\u2010cultures. We show that MCs finely regulate different aspects of splenic B cell biology while peritoneal B cells are unresponsive to the supporting effects provided by MCs. Interestingly, peritoneal B cells induce a pro\u2010inflammatory skewing in MCs, characterized by increased ST2 and TNF\u2010\u03b1 expression. Altogether, this study uncovers the versatility of the B\/MC liaison and highlights key aspects for the resolution of intestinal inflammation.\n                  <\/jats:p>","DOI":"10.1002\/eji.202048668","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T03:22:25Z","timestamp":1600399345000},"page":"445-458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Mast cells crosstalk with B cells in the gut and sustain IgA response in the inflamed intestine"],"prefix":"10.1002","volume":"51","author":[{"given":"Viviana","family":"Valeri","sequence":"first","affiliation":[{"name":"Department of Medicine University of Udine  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Tonon","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Udine  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamila","family":"Vibhushan","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Centre de Recherche sur l'Inflammation, INSERM UMR1149, CNRS ERL8252 Facult\u00e9 de M\u00e9decine site Bichat  Paris France"},{"name":"Universit\u00e9 de Paris, Laboratoire d'excellence INFLAMEX  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Gulino","sequence":"additional","affiliation":[{"name":"Department of Health Science Tumor Immunology Unit Human Pathology Section Palermo University School of Medicine  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Belmonte","sequence":"additional","affiliation":[{"name":"Department of Health Science Tumor Immunology Unit Human Pathology Section Palermo University School of Medicine  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Adori","sequence":"additional","affiliation":[{"name":"Department of Microbiology Tumor and Cell Biology Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunilla B.","family":"Karlsson Hedestam","sequence":"additional","affiliation":[{"name":"Department of Microbiology Tumor and Cell Biology Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Gautier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Centre de Recherche sur l'Inflammation, INSERM UMR1149, CNRS ERL8252 Facult\u00e9 de M\u00e9decine site Bichat  Paris France"},{"name":"Universit\u00e9 de Paris, Laboratoire d'excellence INFLAMEX  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Tripodo","sequence":"additional","affiliation":[{"name":"Department of Health Science Tumor Immunology Unit Human Pathology Section Palermo University School of Medicine  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Blank","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Centre de Recherche sur l'Inflammation, INSERM UMR1149, CNRS ERL8252 Facult\u00e9 de M\u00e9decine site Bichat  Paris France"},{"name":"Universit\u00e9 de Paris, Laboratoire d'excellence INFLAMEX  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Mion","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Udine  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4872-6156","authenticated-orcid":false,"given":"Carlo E.M.","family":"Pucillo","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Udine  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.02.018"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.04.001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2014.02.016"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-10-250126"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302593"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep20531"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI75212"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3337"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","unstructured":"BreitlingS HuiZ ZabiniD HuY HoffmannJ GoldenbergNM TabuchiAet\u00a0al. 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