{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:06:51Z","timestamp":1772118411951,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP\u201077712"],"award-info":[{"award-number":["MOP\u201077712"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In inflammatory bowel disease (IBD), inflammation can occur beyond the intestine and spread systemically causing complications such as arthritis, cachexia, and anemia. Here, we determine the impact of CD45, a pan\u2010leukocyte marker and tyrosine phosphatase, on IBD. Using a mouse model of T cell transfer colitis, CD25\n                    <jats:sup>\u2212<\/jats:sup>\n                    CD45RB\n                    <jats:sup>high<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells were transferred into Rag1\u2010deficient mice (RAGKO) and CD45\u2010deficient RAGKO mice (CD45RAGKO). Weight loss and systemic wasting syndrome were delayed in CD45RAGKO mice compared to RAGKO mice, despite equivalent inflammation in the colon. CD45RAGKO mice had reduced serum levels of TNF\u2010\u03b1, and reduced TNF\u2010\u03b1 production by splenic myeloid cells. CD45RAGKO mice also had increased numbers of erythroid progenitors in the spleen, which had previously been shown to be immunosuppressive. Adoptive transfer of these erythroid progenitors into RAGKO mice reduced their weight loss and TNF\u2010\u03b1 expression by splenic red pulp macrophages. In vitro, erythroid cells suppressed TNF\u2010\u03b1 expression in red pulp macrophages in a phagocytosis\u2010dependent manner. These findings show a novel role for erythroid progenitors in suppressing the pro\u2010inflammatory function of splenic macrophages and cachexia associated with IBD.\n                  <\/jats:p>","DOI":"10.1002\/eji.202048687","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T08:38:16Z","timestamp":1605170296000},"page":"567-579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Splenic erythroid progenitors decrease TNF\u2010\u03b1 production by macrophages and reduce systemic inflammation in a mouse model of T cell\u2010induced colitis"],"prefix":"10.1002","volume":"51","author":[{"given":"Yaein Amy","family":"Shim","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology University of British Columbia  British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asanga","family":"Weliwitigoda","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University of British Columbia  British Columbia Canada"},{"name":"Fred Hutchinson Cancer Research Center  Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University of British Columbia  British Columbia Canada"},{"name":"Division of Human Genetics Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manisha","family":"Dosanjh","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University of British Columbia  British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7367-4653","authenticated-orcid":false,"given":"Pauline","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University of British Columbia  British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(94)90045-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1736"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/39614"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2335"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00705.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.03.012"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070590"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-020711-074950"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101387"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.23"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20092253"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000392"},{"key":"e_1_2_8_14_1","first-page":"1965","article-title":"[Extra\u2010intestinal manifestation of IBD in Veszprem county (of Hungary): results of a 25\u2010years follow\u2010up study]","volume":"144","author":"Lakatos L.","year":"2003","journal-title":"Orv. 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