{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:09:17Z","timestamp":1772118557010,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T00:00:00Z","timestamp":1597622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    NK1.1\n                    <jats:sup>+<\/jats:sup>\n                    cells found in salivary glands (SG) represent a unique cell population of innate lymphoid cells (ILC) with characteristics of both conventional NK\u00a0cells and ILC1. Here, we demonstrate that these NK1.1\n                    <jats:sup>+<\/jats:sup>\n                    \u00a0cells limit the accumulation and differentiation of virus\u2010specific tissue\u2010resident memory CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u00a0cells (T\n                    <jats:sub>RM<\/jats:sub>\n                    \u00a0cells) in SG of mice infected with lymphocytic choriomeningitis virus (LCMV). The negative regulation of LCMV\u2010specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>RM<\/jats:sub>\n                    \u00a0cells by NK1.1\n                    <jats:sup>+<\/jats:sup>\n                    \u00a0cells in SG is independent of NKG2D, NKp46, TRAIL, and perforin. Moreover, analysis of NKp46\n                    <jats:sup>iCre+<\/jats:sup>\n                    Eomes\n                    <jats:sup>fl\/fl<\/jats:sup>\n                    mice revealed that Eomes\u2010dependent conventional NK\u00a0cells are dispensable for negative regulation. Since the SG are prone to autoimmune reactions, regulation of T\n                    <jats:sub>RM<\/jats:sub>\n                    \u00a0cells by tissue\u2010resident ILC may be particularly important to prevent immunopathology in this organ.\n                  <\/jats:p>","DOI":"10.1002\/eji.202048741","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T04:30:02Z","timestamp":1596169802000},"page":"1952-1958","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["NK1.1\n                    <sup>+<\/sup>\n                    innate lymphoid cells in salivary glands inhibit establishment of tissue\u2010resident memory CD8\n                    <sup>+<\/sup>\n                    T\u00a0cells in mice"],"prefix":"10.1002","volume":"50","author":[{"given":"Sandra","family":"Woyciechowski","sequence":"first","affiliation":[{"name":"Institute for Immunology University Medical Center Freiburg Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristoffer","family":"Wei\u00dfert","sequence":"additional","affiliation":[{"name":"Institute for Immunodeficiency Center for Chronic Immunodeficiency (CCI) University Medical Center Freiburg Faculty of Medicine University of Freiburg  Freiburg Germany"},{"name":"Faculty of Biology Albert\u2010Ludwigs\u2010University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Ammann","sequence":"additional","affiliation":[{"name":"Institute for Immunodeficiency Center for Chronic Immunodeficiency (CCI) University Medical Center Freiburg Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Aichele","sequence":"additional","affiliation":[{"name":"Institute for Immunodeficiency Center for Chronic Immunodeficiency (CCI) 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