{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:06:18Z","timestamp":1790838378668,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T00:00:00Z","timestamp":1616112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Studies in murine models show that subthreshold TCR interactions with self\u2010peptide are required for thymic development and peripheral survival of na\u00efve T cells. Recently, differences in the strength of tonic TCR interactions with self\u2010peptide, as read\u2010out by cell surface levels of CD5, were associated with distinct effector potentials among sorted populations of T cells in mice. However, whether CD5 can also be used to parse functional heterogeneity among human T cells is less clear. Our study demonstrates that CD5 levels correlate with TCR signal strength in human na\u00efve CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Further, we describe a relationship between CD5 levels on na\u00efve human CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells and binding affinity to foreign peptide, in addition to a predominance of CD5\n                    <jats:sup>hi<\/jats:sup>\n                    T cells in the memory compartment. Differences in gene expression and biases in cytokine production potential between CD5\n                    <jats:sup>lo<\/jats:sup>\n                    and CD5\n                    <jats:sup>hi<\/jats:sup>\n                    na\u00efve human CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells are consistent with observations in mice. Together, these data validate the use of CD5 surface levels as a marker of heterogeneity among human na\u00efve CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells with important implications for the identification of functionally biased T\u2010 cell populations that can be exploited to improve the efficacy of adoptive cell therapies.\n                  <\/jats:p>","DOI":"10.1002\/eji.202048788","type":"journal-article","created":{"date-parts":[[2021,3,7]],"date-time":"2021-03-07T23:14:22Z","timestamp":1615158862000},"page":"1365-1376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["CD5 levels define functionally heterogeneous populations of na\u00efve human CD4\n                    <sup>+<\/sup>\n                    T cells"],"prefix":"10.1002","volume":"51","author":[{"given":"Aditi","family":"Sood","sequence":"first","affiliation":[{"name":"Immunology\u2010Oncology Unit 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