{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:12:50Z","timestamp":1792631570105,"version":"4.5.0"},"reference-count":60,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T00:00:00Z","timestamp":1611532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["15\/517"],"award-info":[{"award-number":["15\/517"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mucosal associated invariant T (MAIT) cells are anti\u2010microbial innate\u2010like T cells that are abundant in blood and liver. MAIT cells express a semi\u2010invariant T\u2010cell receptor (TCR) that recognizes a pyrimidine ligand, derived from microbial riboflavin synthesis, bound to MR1. Both blood and liver derived (ld)\u2010MAIT cells can be robustly stimulated via TCR or by cytokines produced during bacterial or viral infection. In this study, we compared the functional and transcriptomic response of human blood and ld\u2010MAIT cells to TCR signals (\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    or the pyrimidine ligand) and cytokines (IL\u201012 + IL\u201018). While the response of blood and ld\u2010MAIT cells to TCR signals were comparable, following cytokine stimulation ld\u2010MAIT cells were more polyfunctional than blood MAIT cells. Transcriptomic analysis demonstrated different effector programmes of ld\u2010MAIT cells with the two modes of activation, including the enrichment of a tissue repair signature in TCR\u2010stimulated MAIT cells. Interestingly, we observed enhancement of IL\u201012 signaling and fatty acid metabolism in untreated ld\u2010MAIT cells compared with blood MAIT cells. Additionally, MAIT cells from blood and liver were modulated similarly by TCR and cytokine signals. Therefore, we report that blood and ld\u2010MAIT cells are fundamentally different but undergo conserved changes following activation via TCR or by cytokines.\n                  <\/jats:p>","DOI":"10.1002\/eji.202048830","type":"journal-article","created":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T03:23:47Z","timestamp":1608866627000},"page":"879-892","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Human liver\u2010derived MAIT cells differ from blood MAIT cells in their metabolism and response to TCR\u2010independent activation"],"prefix":"10.1002","volume":"51","author":[{"given":"Rajesh","family":"Lamichhane","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology University of Otago  Dunedin Otago New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran","family":"Munro","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Dunedin School of Medicine University of Otago  Dunedin Otago New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W. R.","family":"Harrop","sequence":"additional","affiliation":[{"name":"Genomics Aotearoa and Department of Biochemistry University of Otago  Dunedin Otago New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara M.","family":"de la Harpe","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Otago  Dunedin Otago New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter K.","family":"Dearden","sequence":"additional","affiliation":[{"name":"Genomics Aotearoa and Department of Biochemistry University of Otago  Dunedin Otago New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea J.","family":"Vernall","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Otago  Dunedin Otago New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L","family":"McCall","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Dunedin School of Medicine University of Otago  Dunedin Otago New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Ussher","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University of Otago  Dunedin Otago New Zealand"},{"name":"Southern Community Laboratories  Dunedin Otago New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01433"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M501087200"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-05-353789"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13160"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12021"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20140507"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00279-12"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1610750113"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201343509"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11653"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21060"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-303339"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004210"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203218"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29782"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.12.017"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.07.043"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.04.009"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2014.81"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01994"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.07.039"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.08.054"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.08.050"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000054"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01031"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201948279"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1812273115"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05202-8"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1705759114"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005072"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms11030789"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830270311"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.033"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4866"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.67"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1804556115"},{"key":"e_1_2_9_38_1","first-page":"79","article-title":"Gut(\u2010)liver axis: how do gut bacteria influence the liver?","volume":"6","author":"Konturek P. C.","year":"2018","journal-title":"Med. Sci. (Basel)"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201545969"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.86292"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.32532"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.3.1901"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15632"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw2719"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax6624"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04450-y"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01347"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.02.010"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21379"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.06.078"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12274"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01664"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.035"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.98487"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20181483"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature24993"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.9.e45"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw419"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.12.033"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-128"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.202048830","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/eji.202048830","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.202048830","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T00:21:10Z","timestamp":1693095670000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.202048830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,25]]},"references-count":60,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/eji.202048830"],"URL":"https:\/\/doi.org\/10.1002\/eji.202048830","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/EJI.202048830\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202048830\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202048830\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202048830\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202048830\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202048830\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202048830\/v2\/review2","asserted-by":"object"}]},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,25]]},"assertion":[{"value":"2020-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}