{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:40:16Z","timestamp":1792215616573,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T00:00:00Z","timestamp":1601251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Thioredoxin\u20101 (Trx1) is a vital component for cellular redox homeostasis. In T\u00a0cells, Trx1 donates electrons for the de novo synthesis of deoxyribonucleotides to allow rapid cell proliferation. The Trx\u2010interacting protein (Txnip) binds to the reduced Trx1 and inhibits its activity. However, the role of Txnip in adaptive immunity in vivo is unknown. Here, we show that absence of Txnip increased proliferation of effector T\u00a0cells and GC B\u2010cell responses in response to lymphocytic choriomeningitis virus and Q\u03b2 virus\u2010like particles, respectively, but did not affect development and homeostasis of T and B cells. While downregulation of Txnip and concomitant upregulation of Trx1 is critical for rapid T\u2010cell expansion upon viral infection, re\u2010expression of Txnip and consequently inhibition of Trx1 is important to restrain late T\u2010cell expansion. Importantly, we demonstrated that T\u2010cell receptor (TCR) engagement but not CD28 costimulation is critically required for Txnip downregulation. Thus, this study further uncovers positive and negative control of lymphocyte proliferation by the Trx1 system.<\/jats:p>","DOI":"10.1002\/eji.202048851","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T03:37:22Z","timestamp":1600054642000},"page":"115-124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["The thioredoxin\u20101 inhibitor Txnip restrains effector T\u2010cell and germinal center B\u2010cell expansion"],"prefix":"10.1002","volume":"51","author":[{"given":"Jonathan","family":"Muri","sequence":"first","affiliation":[{"name":"Institute of Molecular Health Sciences ETH Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Thut","sequence":"additional","affiliation":[{"name":"Institute of Molecular Health Sciences ETH Z\u00fcrich  Z\u00fcrich 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