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To overcome this problem, we here used temporally controlled ablation of mature miRNAs specifically in CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells during acute LCMV infection in mice. T cell\u2010intrinsic miRNA expression was not only critical at early stages of Tfh cell differentiation, but also important for the maintenance of already established Tfh cells. In addition, CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell\u2010specific ablation of miRNAs resulted in impaired GC B cell responses. Notably, miRNA deficiency also compromised the antigen\u2010specific CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell compartment, Th1 cells, Treg cells, and Tfr cells. In conclusion, our results highlight miRNAs as important regulators of Tfh cells, thus providing novel insights into the molecular events that govern T cell\u2013B cell interactions and Th cell identity.\n                  <\/jats:p>","DOI":"10.1002\/eji.202048867","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T08:59:37Z","timestamp":1601456377000},"page":"408-413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["T cell\u2010expressed microRNAs critically regulate germinal center T follicular helper cell function and maintenance in acute viral infection in mice"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9738-6805","authenticated-orcid":false,"given":"Julia","family":"Zeitr\u00e4g","sequence":"first","affiliation":[{"name":"Institute for Immunology Biomedical Center Faculty of Medicine LMU Munich  Planegg\u2010Martinsried 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