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Here, we found that the thymic Treg defect in c\u2010Rel\u2010deficient (\n                    <jats:italic>cRel<\/jats:italic>\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    ) mice is quantitative, not qualitative, based on analyses of TCR repertoire and TCR signaling strength. However, these parameters are altered in the thymic Treg\u2010precursor population, which is also markedly diminished in\n                    <jats:italic>cRel<\/jats:italic>\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice. Moreover, c\u2010Rel governs the transcriptional programme of both thymic and peripheral Tregs, controlling a core of genes involved with immune signaling, and separately in the periphery, cell cycle progression. Last, the immune suppressive function of peripheral\n                    <jats:italic>\n                      cRel\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    tTregs is diminished in a lymphopenic model of T cell proliferation and is associated with decreased stability of Foxp3 expression. Collectively, we show that c\u2010Rel is a transcriptional regulator that controls multiple aspects of Treg development, differentiation, and function via distinct mechanisms.\n                  <\/jats:p>","DOI":"10.1002\/eji.202048900","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T16:50:20Z","timestamp":1620492620000},"page":"2006-2026","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["c\u2010Rel employs multiple mechanisms to promote the thymic development and peripheral function of regulatory T cells in mice"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7210-5739","authenticated-orcid":false,"given":"Thomas S.","family":"Fulford","sequence":"first","affiliation":[{"name":"Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raelene","family":"Grumont","sequence":"additional","affiliation":[{"name":"Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rushika C.","family":"Wirasinha","sequence":"additional","affiliation":[{"name":"Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darcy","family":"Ellis","sequence":"additional","affiliation":[{"name":"Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele","family":"Barugahare","sequence":"additional","affiliation":[{"name":"Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology Monash University  Melbourne Australia"},{"name":"Monash Bioinformatics Platform, School of Biomedical Sciences Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Turner","sequence":"additional","affiliation":[{"name":"Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology Monash University  Melbourne Australia"},{"name":"Department of Microbiology Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haroon","family":"Naeem","sequence":"additional","affiliation":[{"name":"Monash Bioinformatics Platform, School of Biomedical Sciences Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Powell","sequence":"additional","affiliation":[{"name":"Monash Bioinformatics Platform, School of Biomedical Sciences Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7035-8997","authenticated-orcid":false,"given":"Paul A.","family":"Lyons","sequence":"additional","affiliation":[{"name":"Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre University of Cambridge  Cambridge, England UK"},{"name":"Department of Medicine University of Cambridge, University of Cambridge School of Clinical Medicine  Cambridge, England UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3829-4326","authenticated-orcid":false,"given":"Kenneth G. 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