{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T15:45:02Z","timestamp":1784389502355,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The aim of this study is to evaluate the blood level of anti\u2010heart antibodies (AHA) and its correlation with clinical outcomes in patients with severe and moderate coronavirus disease 2019 (COVID\u201019). The study included 34 patients (23 males; mean age 60.2 \u00b1 16.6 years) with COVID\u201019 pneumonia. Besides standard medical examination, the AHA blood levels were observed, including antinuclear antibodies, antiendothelial cell antibodies, anti\u2010cardiomyocyte antibodies (AbC), anti\u2010smooth muscle antibodies (ASMA), and cardiac conducting tissue antibodies. Median hospital length of stay was 14 [13; 18] days. AHA levels were increased in 25 (73.5%) patients. Significant correlation (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05) of AHA levels with cardiovascular manifestations (\n                    <jats:italic>r<\/jats:italic>\n                    = 0.459) was found. AbC levels correlated with pneumonia severity (\n                    <jats:italic>r<\/jats:italic>\n                    = 0.472), respiratory failure (\n                    <jats:italic>r<\/jats:italic>\n                    = 0.387), need for invasive ventilation (\n                    <jats:italic>r<\/jats:italic>\n                    = 0.469), chest pain (\n                    <jats:italic>r<\/jats:italic>\n                    = 0.374), low QRS voltage (\n                    <jats:italic>r<\/jats:italic>\n                    = 0.415), and levels of C\u2010reactive protein (\n                    <jats:italic>r<\/jats:italic>\n                    = 0.360) and lactate dehydrogenase (\n                    <jats:italic>r<\/jats:italic>\n                    = 0.360). ASMA levels were found to correlate with atrial fibrillation (\n                    <jats:italic>r<\/jats:italic>\n                    = 0.414,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Antinuclear antibodies and AbC levels correlated with pericardial effusion (\n                    <jats:italic>r<\/jats:italic>\n                    = 0.721 and\n                    <jats:italic>r<\/jats:italic>\n                    = 0.745, respectively,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). The lethality rate was 8.8%. AbC and ASMA levels correlated significantly with lethality (\n                    <jats:italic>r<\/jats:italic>\n                    = 0.363 and\n                    <jats:italic>r<\/jats:italic>\n                    = 0.426, respectively,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05) and were prognostically important. AHA can be considered as part of the systemic immune and inflammatory response in COVID\u201019. Its possible role in the inflammatory heart disease requires further investigation.\n                  <\/jats:p>","DOI":"10.1002\/eji.202048930","type":"journal-article","created":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T04:49:38Z","timestamp":1608871778000},"page":"893-902","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Anti\u2010heart antibodies levels and their correlation with clinical symptoms and outcomes in patients with confirmed or suspected diagnosis COVID\u201019"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5253-793X","authenticated-orcid":false,"given":"Olga","family":"Blagova","sequence":"first","affiliation":[{"name":"The First I.M. Sechenov Moscow State Medical University (Sechenov University)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadezhda","family":"Varionchik","sequence":"additional","affiliation":[{"name":"The First I.M. Sechenov Moscow State Medical University (Sechenov University)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Zaidenov","sequence":"additional","affiliation":[{"name":"Moscow City Clinical Hospital No. 52  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polina","family":"Savina","sequence":"additional","affiliation":[{"name":"The First I.M. Sechenov Moscow State Medical University (Sechenov University)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Sarkisova","sequence":"additional","affiliation":[{"name":"The First I.M. Sechenov Moscow State Medical University (Sechenov University)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30628-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.18087\/cardio.2020.7.n1209"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa248"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102524"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25832"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.140711"},{"key":"e_1_2_8_9_1","article-title":"Distribution of HLA allele frequencies in 82 Chinese individuals with coronavirus disease\u20102019 (COVID\u201019) [published online ahead of print, 2020 May 19]","author":"Wang W.","year":"2020","journal-title":"HLA"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.20-0240"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.03.053"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-0360-5"},{"key":"e_1_2_8_13_1","article-title":"SARS\u2010CoV\u20102\u2010related myocarditis\u2010like syndromes Shakespeare's question: what's in a name? [published online ahead of print, 2020 May 19]","author":"Van Linthout S.","year":"2020","journal-title":"Eur. J. Heart Fail."},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-010-8229-8"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.187138"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.043931"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000499865"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.0950"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217424"},{"key":"e_1_2_8_20_1","article-title":"Detection of viral SARS\u2010CoV\u20102 genomes and histopathological changes in endomyocardial biopsies","volume":"12","author":"Escher F.","year":"2020","journal-title":"ESC Heart Fail."},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa160"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa286"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeaa107"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.202048930","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/eji.202048930","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.202048930","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T00:20:51Z","timestamp":1693095651000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.202048930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,27]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/eji.202048930"],"URL":"https:\/\/doi.org\/10.1002\/eji.202048930","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/EJI.202048930\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202048930\/v2\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202048930\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202048930\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202048930\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202048930\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202048930\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202048930\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202048930\/v3\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202048930\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202048930\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202048930\/v3\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202048930\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202048930\/v2\/response1","asserted-by":"object"}]},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,27]]},"assertion":[{"value":"2020-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}