{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:57:07Z","timestamp":1791889027956,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Low concentrations of type\u2010I interferon (IFN) in blood seem to be associated with more severe forms of Coronavirus disease 2019 (COVID\u201019). However, following the type\u2010I interferon response (IR) in early stage disease is a major challenge. We evaluated detection of a molecular interferon signature on a FilmArray\u00ae system, which includes PCR assays for four interferon stimulated genes. We analyzed three types of patient populations: (i) children admitted to a pediatric emergency unit for fever and suspected infection, (ii) ICU\u2010admitted patients with severe COVID\u201019, and (iii) healthcare workers with mild COVID\u201019. The results were compared to the reference tools, that is, molecular signature assessed with Nanostring\u00ae and IFN\u2010\u03b12 quantification by SIMOA\u00ae (Single MOlecule Array). A strong correlation was observed between the IR measured by the FilmArray\u00ae, Nanostring\u00ae, and SIMOA\u00ae platforms (r\u2010Spearman 0.996 and 0.838, respectively). The FilmArray\u00ae panel could be used in the COVID\u201019 pandemic to evaluate the IR in 45\u2010min with 2 min hand\u2010on\u2010time at hospitalization and to monitor the IR in future clinical trials.<\/jats:p>","DOI":"10.1002\/eji.202048978","type":"journal-article","created":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T02:35:13Z","timestamp":1607826913000},"page":"989-994","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Type\u2010I Interferon assessment in 45 minutes using the FilmArray\n                    <sup>\u00ae<\/sup>\n                    PCR platform in SARS\u2010CoV\u20102 and other viral infections"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5624-7756","authenticated-orcid":false,"given":"Marine","family":"Mommert","sequence":"first","affiliation":[{"name":"Joint Research Unit Hospices Civils de Lyon\u2010bioM\u00e9rieux Lyon Sud Hospital  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University  INSERM U1111, CNRS UMR 5308, ENS, UCBL Lyon France"},{"name":"Immunology Laboratory Hospices Civils de Lyon,\u00a0 Lyon Sud Hospital, Pierre\u2010B\u00e9nite"},{"name":"National Referee Centre for Rheumatic and AutoImmune and Systemic diseases in ChildrEn (RAISE)"},{"name":"Lyon Immunopathology Federation LIFE Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Belot","sequence":"additional","affiliation":[{"name":"International Center of Research in Infectiology Lyon University  INSERM U1111, CNRS UMR 5308, ENS, UCBL Lyon France"},{"name":"National Referee Centre for Rheumatic and AutoImmune and Systemic diseases in childrEn (RAISE)  Lyon France"},{"name":"Lyon Immunopathology Federation LIFE Hospices Civils de Lyon  Lyon France"},{"name":"Pediatric Nephrology Rheumatology Dermatology Unit, Hospices Civils de Lyon  Lyon 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of Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"ANTOINE Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"COVID\u2010SER Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"COVID\u2010HCL Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hemmert","sequence":"additional","affiliation":[{"name":"BioFire Diagnostics, LLC  Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Mallet","sequence":"additional","affiliation":[{"name":"Joint Research Unit Hospices Civils de Lyon\u2010bioM\u00e9rieux Lyon Sud Hospital  Pierre\u2010B\u00e9nite France"},{"name":"EA 7426 Pathophysiology of Injury\u2010Induced Immunosuppression Edouard Herriot Hospital University of Lyon1\u2010Hospices Civils de 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