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While the infection with human CoV is commonly associated with mild respiratory symptoms, the emergence of SARS\u2010CoV, MERS\u2010CoV, and SARS\u2010CoV\u20102 highlights the potential for CoVs to cause severe respiratory and systemic disease. The devastating global health burden caused by SARS\u2010CoV\u20102 has spawned countless studies seeking clinical correlates of disease severity and host susceptibility factors, revealing a complex network of antiviral immune circuits. The mouse hepatitis virus (MHV) is, like SARS\u2010CoV\u20102, a beta\u2010CoV and is endemic in wild mice. Laboratory MHV strains have been extensively studied to reveal coronavirus virulence factors and elucidate host mechanisms of antiviral immunity. These are reviewed here with the aim to identify translational insights for SARS\u2010CoV\u20102 learned from murine CoVs.<\/jats:p>","DOI":"10.1002\/eji.202048984","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T11:23:46Z","timestamp":1615289026000},"page":"1062-1070","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Insights into coronavirus immunity taught by the murine coronavirus"],"prefix":"10.1002","volume":"51","author":[{"given":"Sarah","family":"Grabherr","sequence":"first","affiliation":[{"name":"Institute of Immunobiology, Medical Research Center Kantonsspital St. Gallen  St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7685-573X","authenticated-orcid":false,"given":"Burkhard","family":"Ludewig","sequence":"additional","affiliation":[{"name":"Institute of Immunobiology, Medical Research Center 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