{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:00:44Z","timestamp":1790834444439,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Although the COVID\u201019 pandemic peaked in March\/April 2020 in France, the prevalence of infection is barely known. Using high\u2010throughput methods, we assessed herein the serological response against the severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) of 1847 participants working in three sites of an institution in Paris conurbation.<\/jats:p>\n                  <jats:p>In May\u2013July 2020, 11% (95% confidence interval [CI]: 9.7\u201312.6) of serums were positive for IgG against the SARS\u2010CoV\u20102 N and S proteins, and 9.5% (95% CI: 8.2\u201311.0) were neutralizer in pseudo\u2010typed virus assays. The prevalence of seroconversion was 11.6% (95% CI: 10.2\u201313.2) when considering positivity in at least one assay. In 5% of RT\u2010qPCR positive individuals, no systemic IgGs were detected. Among immune individuals, 21% had been asymptomatic. Anosmia (loss of smell) and ageusia (loss of taste) occurred in 52% of the IgG\u2010positive individuals and in 3% of the negative ones. In contrast, 30% of the anosmia\u2013ageusia cases were seronegative, suggesting that the true prevalence of infection may have reached 16.6%. In sera obtained 4\u20138 weeks after the first sampling, anti\u2010N and anti\u2010S IgG titers and neutralization activity in pseudo\u2010virus assay declined by 31%, 17%, and 53%, resulting thus in half\u2010life of 35, 87, and 28 days, respectively.<\/jats:p>\n                  <jats:p>The population studied is representative of active workers in Paris. The short lifespan of the serological systemic responses suggests an underestimation of the true prevalence of infection.<\/jats:p>","DOI":"10.1002\/eji.202049058","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T18:53:32Z","timestamp":1606848812000},"page":"180-190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["High seroprevalence but short\u2010lived immune response to SARS\u2010CoV\u20102 infection in Paris"],"prefix":"10.1002","volume":"51","author":[{"given":"Fran\u00e7ois","family":"Anna","sequence":"first","affiliation":[{"name":"Theravectys  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Goyard","sequence":"additional","affiliation":[{"name":"Unit of Lymphocyte Cell Biology Immunology Department, Institut Pasteur  Paris France"},{"name":"INSERM 1221 Institut Pasteur  Paris 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