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As a result, the enteric immune system has evolved so as not to cause a zero\u2010sum sterilization of non\u2010self, but rather achieve a non\u2010zero\u2010sum self\u2010reinforcing cooperation with its evolutionary partner the microbiome. In this review, we attempt to integrate the accumulated knowledge of immune\u2014microbiome interactions into an evolutionary framework and trace the pattern of positive immune\u2014microbiome feedback loops across epithelial, enteric nervous system, innate, and adaptive immune circuits. Indeed, the immune system requires commensal signals for its development and function, and reciprocally protects the microbiome from nutrient shortage and pathogen outgrowth. In turn, a healthy microbiome is the result of immune system curatorship as well as microbial ecology. The paradigms of host\u2013microbiome asymmetry and the cooperative nature of their interactions identified in the gut are applicable across all tissues influenced by microbial activities. Incorporation of immune system influences into models of microbiome ecology will be a step forward toward defining what constitutes a healthy human microbiome and guide discoveries of novel host\u2013microbiome mutualistic adaptations that may be harnessed for the promotion of human health.<\/jats:p>","DOI":"10.1002\/eji.202049065","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T16:19:25Z","timestamp":1625847565000},"page":"2120-2136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Non\u2010zero\u2010sum microbiome immune system interactions"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4940-0000","authenticated-orcid":false,"given":"Timur","family":"Tuganbaev","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8937-9835","authenticated-orcid":false,"given":"Kenya","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Keio University School of Medicine  Tokyo Japan"},{"name":"RIKEN Center for Integrative Medical Sciences  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.07.008"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-018-1590-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2021.02.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature24287"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.45"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803124105"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317571"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.11.014"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0567-y"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2039-9"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.12.023"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13823"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-018-0053-0"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1515\/9781400829460"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01407-5"},{"key":"e_1_2_7_17_1","unstructured":"Wright R. 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