{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:18:22Z","timestamp":1790731102324,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T00:00:00Z","timestamp":1613692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Antibodies play an important role in host defense against microorganisms. Besides direct microbicidal activities, antibodies can also provide indirect protection via crosstalk to constituents of the adaptive immune system. Similar to many human chronic viral infections, persistence of Lymphocytic choriomeningitis virus (LCMV) is associated with compromised T\u2010 and B\u2010cell responses. The administration of virus\u2010specific non\u2010neutralizing antibodies (nnAbs) prior to LCMV infection protects against the establishment of chronic infection. Here, we show that LCMV\u2010specific nnAbs bind preferentially Ly6C\n                    <jats:sup>hi<\/jats:sup>\n                    inflammatory monocytes (IMs), promote their infection in an Fc\u2010receptor independent way, and support acquisition of APC properties. By constituting additional T\u2010cell priming opportunities, IMs promote early activation of virus\u2010specific CD8 T cells, eventually tipping the balance between T\u2010cell exhaustion and effector cell differentiation, preventing establishment of viral persistence without causing lethal immunopathology. These results document a beneficial role of IMs in avoiding T\u2010cell exhaustion and an Fc\u2010receptor independent protective mechanism provided by LCMV\u2010specific nnAbs against the establishment of chronic infection.\n                  <\/jats:p>","DOI":"10.1002\/eji.202049068","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T06:26:24Z","timestamp":1612592784000},"page":"1423-1435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Non\u2010neutralizing antibodies protect against chronic LCMV infection by promoting infection of inflammatory monocytes in mice"],"prefix":"10.1002","volume":"51","author":[{"given":"Diana","family":"Stoycheva","sequence":"first","affiliation":[{"name":"Institute of Microbiology ETH Z\u00fcrich  Zurich 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Der Maaten L.andHinton G.. 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