{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:48:06Z","timestamp":1790693286863,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T00:00:00Z","timestamp":1624665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701474"],"award-info":[{"award-number":["81701474"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010242","name":"Jiangsu Planned Projects for Postdoctoral Research Funds","doi-asserted-by":"publisher","award":["2018K041A"],"award-info":[{"award-number":["2018K041A"]}],"id":[{"id":"10.13039\/501100010242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Intrauterine adhesions (IUA) are characterized by endometrial fibrosis and impose a great challenge for female reproduction. IL\u201034 is profoundly involved in various fibrotic diseases through regulating the survival, proliferation, and differentiation of monocytes\/macrophages. However, it remains unclear how IL\u201034 regulates monocytes\/macrophages in context of IUA. Here, we showed that the expression level of IL\u201034 and the amount of CX3CR1+ monocytes\/macrophages were significantly increased in endometrial tissues of IUA patients. IL\u201034 promoted the differentiation of monocytes\/macrophages, which express CX3CR1 via CSF\u20101R\/P13K\/Akt pathway in vitro. Moreover, IL\u201034\u2010induced CX3CR1+ monocytes\/macrophages promoted the differentiation of endometrial stromal cells into myofibroblasts. Of note, IL\u201034 caused endometrial fibrosis and increased the amount of CX3CR1+ monocytes\/macrophages in endometrial tissues in vivo. IL\u201034 modulated endometrial fibrosis by regulating monocytes\/macrophages since the elimination of endometrial monocytes\/macrophages significantly suppressed the profibrotic function of IL\u201034. Finally, blocking of IL\u201034 in the LPS\u2010IUA model resulted in the improvement of endometrial fibrosis and decreased number of CX3CR1+ monocytes\/macrophages. Our studies uncover the novel mechanism of interaction between IL\u201034\u2010induced CX3CR1+ monocytes\/macrophages and endometrial stromal cells in endometrial fibrosis pathogenesis, and highlight IL\u201034 as a critical target for treating IUA.<\/jats:p>","DOI":"10.1002\/eji.202149174","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T10:35:21Z","timestamp":1623926121000},"page":"2501-2512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Interleukin\u201034 accelerates intrauterine adhesions progress related to CX3CR1\n                    <sup>+<\/sup>\n                    monocytes\/macrophages"],"prefix":"10.1002","volume":"51","author":[{"given":"Jiali","family":"Wang","sequence":"first","affiliation":[{"name":"The State Key Laboratory of Pharmaceutical Biotechnology Division of Immunology Medical School Nanjing University  Nanjing 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