{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:08:36Z","timestamp":1772118516801,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T00:00:00Z","timestamp":1630627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008672","name":"Wilhelm Sander-Stiftung","doi-asserted-by":"publisher","award":["2020.045.1"],"award-info":[{"award-number":["2020.045.1"]}],"id":[{"id":"10.13039\/100008672","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Treatment with convalescent plasma has been shown to be safe in coronavirus disease in 2019 (COVID\u201019) infection, although efficacy reported in immunocompetent patients varies. Nevertheless, neutralizing antibodies are a key requisite in the fight against viral infections. Patients depleted of antibody\u2010producing B cells, such as those treated with rituximab (anti\u2010CD20) for hematological malignancies, lack a fundamental part of their adaptive immunity. Treatment with convalescent plasma appears to be of general benefit in this particularly vulnerable cohort. We analyzed clinical course and inflammation markers of three B\u2010cell\u2010depleted patients suffering from COVID\u201019 who were treated with convalescent plasma. In addition, we measured serum antibody levels as well as peripheral blood CD38\/HLA\u2010DR\u2010positive T\u2010cells ex vivo and CD137\u2010positive T\u2010cells after in vitro stimulation with severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102)\u2010derived peptides in these patients. We observed that therapy with convalescent plasma was effective in all three patients and analysis of CD137\u2010positive T\u2010cells after stimulation with SARS\u2010CoV\u20102 peptides showed an increase in peptide\u2010specific T\u2010cells after application of convalescent plasma.<\/jats:p>\n                  <jats:p>In conclusion, we here demonstrate efficacy of convalescent plasma therapy in three B\u2010cell\u2010depleted patients and present data that suggest that while application of convalescent plasma elevates systemic antibody levels only transiently, it may also boost specific T\u2010cell responses.<\/jats:p>","DOI":"10.1002\/eji.202149277","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T02:42:55Z","timestamp":1628131375000},"page":"2478-2484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Successful treatment of COVID\u201019 infection with convalescent plasma in B\u2010cell\u2010depleted patients may promote cellular immunity"],"prefix":"10.1002","volume":"51","author":[{"given":"Andreas E.","family":"Kremer","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"},{"name":"Department of Internal Medicine 1 Gastroenterology, Pneumology and Endocrinology University Hospital Erlangen and Friedrich\u2010Alexander\u2010University of Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita N.","family":"Kremer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 5 Hematology and Oncology University Hospital Erlangen and Friedrich\u2010Alexander\u2010University Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Willam","sequence":"additional","affiliation":[{"name":"Department of Internal 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