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The capsule, composed predominantly of the capsular polysaccharide (CP) GXM, is the main virulence factor of this pathogen. The role of CP is well described for <jats:italic>C. neoformans<\/jats:italic> and; however, there is a scarcity of studies focused on <jats:italic>C. gattii<\/jats:italic>, especially in the context of the fungal\u2013host interaction. Understanding how the immune system recognizes <jats:italic>C. gattii<\/jats:italic> can generate meaningful information for diagnosing, preventing, and treating cryptococcosis. In the current issue of the <jats:italic>European Journal of Immunology<\/jats:italic> [Eur. J. Immunol. 2021. 51: 2281\u20132295], Ueno et\u00a0al. demonstrate that CP inhibits <jats:italic>C. gattii<\/jats:italic> recognition by CD11b. In this commentary, we highlight the importance of deeply understanding the role of <jats:italic>C. gattii<\/jats:italic> CP during infection and how this knowledge would influence the strategies to develop new vaccines against cryptococcosis.<\/jats:p>","DOI":"10.1002\/eji.202149349","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T04:39:49Z","timestamp":1629088789000},"page":"2206-2209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["<i>Cryptococcus gattii<\/i> polysaccharide capsule: An insight on fungal\u2010host interactions and vaccine studies"],"prefix":"10.1002","volume":"51","author":[{"given":"Gustavo J. 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