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Using a lymphocytic choriomeningitis virus (LCMV) Armstrong infection mouse model, we found that Treg cell\u2010derived interleukin (IL)\u201015 is required for long\u2010term maintenance of the KLRG1\n                    <jats:sup>+<\/jats:sup>\n                    IL\u20107R\u03b1\n                    <jats:sup>\u2212<\/jats:sup>\n                    CD62L\n                    <jats:sup>\u2212<\/jats:sup>\n                    terminal effector memory CD8\n                    <jats:sup>+<\/jats:sup>\n                    T (tTEM) cell subset, but dispensable for the suppressive function of Treg cells themselves. In contrast, deletion of\n                    <jats:italic>Il15<\/jats:italic>\n                    from other sources, including myeloid cells and muscles, did not affect the composition of the memory CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell pool. Our findings identify Treg cells as an essential IL\u201015 source maintaining tTEM cells and suggest that Treg cells promote the diversity of immunological memory.\n                  <\/jats:p>","DOI":"10.1002\/eji.202149400","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T05:13:30Z","timestamp":1666242810000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Regulatory T cell\u2010derived interleukin\u201015 promotes the diversity of immunological memory"],"prefix":"10.1002","volume":"53","author":[{"given":"Alaa","family":"Madi","sequence":"first","affiliation":[{"name":"T Cell Metabolism Group (D192) German Cancer Research Center (DKFZ)  Im Neuenheimer Feld 280 69120 Heidelberg Germany"},{"name":"Faculty of Biosciences Heidelberg University  69120 Heidelberg 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