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However, much of the current information on human T\u2010cell memory is based on analyzing circulating T cells. Here, we have studied the distribution and age\u2010related changes of memory T\u2010cell subsets in samples from blood, mesenteric LNs, spleen, and ileum, obtained from donors ranging in age from 5 days to 67 years of age. Our data show that the main reservoir of polyclonal naive cells is found in the LNs, and the resting memory subsets capable of self\u2010renewal are also prominent there. In contrast, nondividing but functionally active memory subsets dominate the spleen, and especially the ileum. In general, the replacement of naive cells with memory subsets continues throughout our period of observation, with no apparent plateau. In conclusion, the analysis of lymphoid and nonlymphoid tissues reveals a dynamic pattern of changes distinct to each tissue, and with substantial differences between CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    compartments.\n                  <\/jats:p>","DOI":"10.1002\/eji.202149465","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T04:25:13Z","timestamp":1647836713000},"page":"882-894","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Peripheral differentiation patterns of human T cells"],"prefix":"10.1002","volume":"52","author":[{"given":"Nelli","family":"Heikkil\u00e4","sequence":"first","affiliation":[{"name":"Translational Immunology Research Program (TRIMM), Research Programs Unit (RPU) Department of Bacteriology and Immunology, Medicum, Faculty of Medicine University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iivo","family":"Hetem\u00e4ki","sequence":"additional","affiliation":[{"name":"Translational Immunology Research Program (TRIMM), Research Programs Unit (RPU) Department of Bacteriology and Immunology, Medicum, Faculty of Medicine University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silja","family":"Sormunen","sequence":"additional","affiliation":[{"name":"Department of Computer Science Aalto University  Espoo Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Isoniemi","sequence":"additional","affiliation":[{"name":"Division of Transplantation and Liver Surgery Helsinki University Central Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliisa","family":"Kek\u00e4l\u00e4inen","sequence":"additional","affiliation":[{"name":"Translational Immunology Research Program (TRIMM), Research Programs Unit (RPU) Department of Bacteriology and Immunology, Medicum, Faculty of Medicine HUSLAB Clinical Microbiology University of Helsinki, and Helsinki University Central Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jari","family":"Saram\u00e4ki","sequence":"additional","affiliation":[{"name":"Department of Computer Science Aalto University  Espoo Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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