{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:14:17Z","timestamp":1783016057928,"version":"3.54.6"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T00:00:00Z","timestamp":1636243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The capacity to develop immunological memory is a hallmark of the adaptive immune system. To investigate the role of\n                    <jats:italic>Samd3 for cellular immune responses and memory development<\/jats:italic>\n                    , we generated a conditional knock\u2010out mouse including a fluorescent reporter and a huDTR cassette for conditional depletion of Samd3\u2010expressing cells.\n                    <jats:italic>Samd3<\/jats:italic>\n                    expression was observed in NK cells and CD8 T cells, which are known for their specific function against intracellular pathogens like viruses. After acute viral infections,\n                    <jats:italic>Samd3<\/jats:italic>\n                    expression was enriched within memory precursor cells and the frequency of\n                    <jats:italic>Samd3<\/jats:italic>\n                    \u2010expressing cells increased during the progression into the memory phase. Similarly, during chronic viral infections,\n                    <jats:italic>Samd3<\/jats:italic>\n                    expression was predominantly detected within precursors of exhausted CD8 T cells that are critical for viral control. At the functional level however,\n                    <jats:italic>Samd3<\/jats:italic>\n                    \u2010deficient CD8 T cells were not compromised in the context of acute infection with\n                    <jats:italic>Vaccinia<\/jats:italic>\n                    virus or chronic infection with Lymphocytic choriomeningitis virus. Taken together, we describe a novel multifunctional mouse model to study the role of\n                    <jats:italic>Samd3<\/jats:italic>\n                    and\n                    <jats:italic>Samd3<\/jats:italic>\n                    \u2010expressing cells. We found that\n                    <jats:italic>Samd3<\/jats:italic>\n                    is specifically expressed in NK cells, memory CD8 T cells, and precursor exhausted T cells during viral infections, while the molecular function of this enigmatic gene remains further unresolved.\n                  <\/jats:p>","DOI":"10.1002\/eji.202149469","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T09:44:24Z","timestamp":1633772664000},"page":"328-337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A multifunctional mouse model to study the role of Samd3"],"prefix":"10.1002","volume":"52","author":[{"given":"Annika E.","family":"Peters","sequence":"first","affiliation":[{"name":"W\u00fcrzburg Institute of Systems Immunology Max Planck Research Group at the Julius\u2010Maximilians\u2010Universit\u00e4t W\u00fcrzburg  Wurzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Kn\u00f6pper","sequence":"additional","affiliation":[{"name":"W\u00fcrzburg Institute of Systems Immunology Max Planck Research Group at the Julius\u2010Maximilians\u2010Universit\u00e4t W\u00fcrzburg  Wurzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"Grafen","sequence":"additional","affiliation":[{"name":"W\u00fcrzburg Institute of Systems Immunology Max Planck Research Group at the Julius\u2010Maximilians\u2010Universit\u00e4t W\u00fcrzburg  Wurzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Kastenm\u00fcller","sequence":"additional","affiliation":[{"name":"W\u00fcrzburg Institute of Systems Immunology Max Planck Research Group at the Julius\u2010Maximilians\u2010Universit\u00e4t W\u00fcrzburg  Wurzburg 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