{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:38:20Z","timestamp":1792111100069,"version":"4.4.0"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Psoriasis is a chronic inflammatory skin disease characterized by Th17 responses. Recent evidence has identified Langerhans cells to have a key role in disease pathogenesis, with constitutive high expression of CD1a and capacity to present lipid antigens to T cells. Phospholipase A\n                    <jats:sub>2<\/jats:sub>\n                    enzymes generate neolipid antigens for recognition by CD1a\u2010reactive T cells; however, the broader enzymatic pathways of CD1a lipid ligand generation have not been thoroughly investigated. In this study, we used immunofluorescence of skin and ELISpot analyses of CD1a\u2010reactive T cells to investigate the role of the lipase acyloxyacyl hydrolase (AOAH) in CD1a ligand generation with relevance to the pathogenesis of psoriasis. We found that the PLA\n                    <jats:sub>2<\/jats:sub>\n                    activity of rAOAH leads to the activation of circulating CD1a auto\u2010reactive T cells, leading to the production of IFN\u2010\u03b3 and IL\u201022. Circulating AOAH\u2010responsive CD1a\u2010reactive T cells from patients with psoriasis showed elevated IL\u201022 production. We observed that AOAH is highly expressed in psoriatic lesions compared to healthy skin. Overall, these data present a role for AOAH in generating antigens that activate circulating lipid\u2010specific CD1a\u2010restricted T cells and, thus, contribute to psoriatic inflammation. These findings suggest that inhibition of PLA\n                    <jats:sub>2<\/jats:sub>\n                    activity of AOAH may have therapeutic potential for individuals with psoriasis.\n                  <\/jats:p>","DOI":"10.1002\/eji.202149485","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T06:05:04Z","timestamp":1639634704000},"page":"511-524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Phospholipase activity of acyloxyacyl hydrolase induces IL\u201022\u2010producing CD1a\u2010autoreactive T cells in individuals with psoriasis"],"prefix":"10.1002","volume":"52","author":[{"given":"Randeep","family":"Singh","sequence":"first","affiliation":[{"name":"Medical Research Council Human Immunology Unit Radcliffe Department of Medicine Medical Research Council Weatherall Institute of Molecular Medicine University of Oxford  Oxford 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