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Growing evidence suggests that the roles of the pancreas extend to not only the secretion of digestive enzymes and hormones but also to the regulation of intestinal homeostasis and inflammation (e.g., mucosal defense to pathogens and pathobionts). Organ crosstalk between the pancreas and intestine is linked to a range of physiological, immunological, and pathological activities, such as the regulation of the gut microbiota by the pancreatic proteins and lipids, the retroaction of the gut microbiota on the pancreas, the relationship between inflammatory bowel disease, and pancreatic diseases. We herein discuss the current understanding of the pancreas\u2013intestinal barrier axis and the control of commensal bacteria in intestinal inflammation.<\/jats:p>","DOI":"10.1002\/eji.202149532","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T13:24:25Z","timestamp":1651065865000},"page":"1035-1046","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Intestinal homeostasis and inflammation: Gut microbiota at the crossroads of pancreas\u2013intestinal barrier axis"],"prefix":"10.1002","volume":"52","author":[{"given":"Zhongwei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Innovative Medicine Graduate School of Medicine Chiba University  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izumi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Innovative Medicine Graduate School of Medicine Chiba 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