{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:09:33Z","timestamp":1772118573386,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T00:00:00Z","timestamp":1640304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004243","name":"Prinses Beatrix Spierfonds","doi-asserted-by":"publisher","award":["W.OR19\u201024"],"award-info":[{"award-number":["W.OR19\u201024"]}],"id":[{"id":"10.13039\/501100004243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Clinical efficacy of intravenous immunoglobulin treatment (IVIg) is related to its pharmacokinetic (PK) profile. Its usual evaluation, by measuring serum total IgG levels, is imprecise, because IVIg cannot be distinguished from endogenous IgG. We developed ELISAs to specifically monitor the PK of IVIg using the polymorphic determinants G1m(a), G1m(x), and G1m(f). The specificity of the IgG1 allotype assays was sufficient to determine IVIg concentrations as low as 0.1 mg\/mL in sera from individuals not expressing the respective markers. IVIg was quantified in posttreatment serum from patients with Guillain\u2013Barr\u00e9 syndrome (GBS) by measuring IgG1 allotypes not expressed endogenously. After serotyping, 27\/28 GBS patients were found eligible for IVIg monitoring using one or two genetic markers. In 17 cases, IVIg levels could be determined by both anti\u2010G1m(a) and anti\u2010G1m(x) measurement, showing significant correlation. Longitudinal monitoring of IVIg PK in seven GBS patients showed potential differences in clearance of total IgG versus IVIg\u2010derived IgG, highlighting that total IgG measurements may not accurately reflect IVIg PK. To summarize, anti\u2010IgG1 allotype assays can discriminate between endogenous IgG and therapeutic polyclonal IgG. These assays will be an important tool to better understand the variability in IVIg PK and treatment response of all patients treated with IVIg.<\/jats:p>","DOI":"10.1002\/eji.202149653","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T05:43:10Z","timestamp":1638423790000},"page":"609-617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Novel approach to monitor intravenous immunoglobulin pharmacokinetics in humans using polymorphic determinants in IgG1 constant domains"],"prefix":"10.1002","volume":"52","author":[{"given":"Sander J.","family":"van Tilburg","sequence":"first","affiliation":[{"name":"Department of Immunology Erasmus MC University Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart C.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Immunology Erasmus MC University Medical Center  Rotterdam The Netherlands"},{"name":"Department of Neurology Erasmus MC University Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pleuni","family":"Ooijevaar\u2010de Heer","sequence":"additional","affiliation":[{"name":"Department of Immunopathology Sanquin Research and Landsteiner Laboratory  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem\u2010Jan R.","family":"Fokkink","sequence":"additional","affiliation":[{"name":"Department of Immunology Erasmus MC University Medical Center  Rotterdam The Netherlands"},{"name":"Department of Neurology Erasmus MC University Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Huizinga","sequence":"additional","affiliation":[{"name":"Department of Immunology Erasmus MC University Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gestur","family":"Vidarsson","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunohematology Sanquin Research and Landsteiner Laboratory  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9600-1312","authenticated-orcid":false,"given":"Theo","family":"Rispens","sequence":"additional","affiliation":[{"name":"Department of Immunopathology Sanquin Research and Landsteiner Laboratory  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.253"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3401"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2008.06.006"},{"key":"e_1_2_9_5_1","first-page":"1","article-title":"Metabolism of immunoglobulins","volume":"13","author":"Waldmann T. 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