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B cells are directly and indirectly involved in the pathophysiology of autoimmunity, both via antigen\u2010presentation to T cells and production of proinflammatory cytokines and\/or autoantibodies. Consequently, B lineage cells have been identified as therapeutic targets in autoimmune diseases. B cell depleting strategies have proven beneficial in the treatment of rheumatoid arthritis (RA), systemic lupus erythematous (SLE), ANCA\u2010associated vasculitis (AAV), multiple sclerosis (MS), and a wide range of other immune\u2010mediated inflammatory diseases (IMIDs). However, not all patients respond to treatment or may not reach (drug\u2010free) remission. Moreover, B cell depleting therapies do not always target all B cell subsets, such as short\u2010lived and long\u2010lived plasma cells. These cells play an active role in autoimmunity and in certain diseases their depletion would be beneficial to achieve disease remission. In the current review article, we provide an overview of novel strategies to target B lineage cells in autoimmune diseases, with the focus on rheumatic diseases. Both advanced therapies that have recently become available and more experimental treatments that may reach the clinic in the near future are discussed.<\/jats:p>","DOI":"10.1002\/eji.202149675","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T05:23:22Z","timestamp":1667193802000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Targeting B cells and plasma cells in autoimmune diseases: From established treatments to novel therapeutic approaches"],"prefix":"10.1002","volume":"53","author":[{"given":"Ana","family":"Merino\u2010Vico","sequence":"first","affiliation":[{"name":"Department of Experimental Immunology Amsterdam University Medical Centers University of Amsterdam  Amsterdam Netherlands"},{"name":"Department of Clinical Immunology and Rheumatology Amsterdam Rheumatology and Immunology Center Amsterdam University Medical Centers University of Amsterdam  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