{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:58:30Z","timestamp":1787065110127,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Infection of mice with\n                    <jats:italic>Nippostrongylus brasiliensis<\/jats:italic>\n                    (\n                    <jats:italic>Nb<\/jats:italic>\n                    ) serves as a model for human hookworm infection affecting about 600 million people world\u2010wide. Expulsion of\n                    <jats:italic>Nb<\/jats:italic>\n                    from the intestine requires IL\u201013\u2010mediated mucus secretion from goblet cells and activation of smooth muscles cells. Type 2 innate lymphoid cells (ILC2s) are a major cellular source of IL\u201013 but it remains unclear whether IL\u201013 secretion from ILC2s is required for\n                    <jats:italic>Nb<\/jats:italic>\n                    expulsion. Here, we compared the immune response to\n                    <jats:italic>Nb<\/jats:italic>\n                    infection in mixed bone marrow chimeras with wild\u2010type or IL\u20104\/IL\u201013\u2010deficient ILC2s. ILC2\u2010derived IL\u20104\/IL\u201013 was required for recruitment of eosinophils to the lung but had no influence of systemic eosinophil levels. In the small intestine, goblet cell hyperplasia and tuft cell accumulation was largely dependent on IL\u20104\/IL\u201013 secretion from ILC2s. This further translated to higher eggs counts and impaired worm expulsion in mice with IL\u20104\/IL\u201013\u2010deficient ILC2s. Overall, we demonstrate that ILC2s constitute a non\u2010redundant source of IL\u20104\/IL\u201013 required for protective immunity against primary\n                    <jats:italic>Nb<\/jats:italic>\n                    infection.\n                  <\/jats:p>","DOI":"10.1002\/eji.202249892","type":"journal-article","created":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T06:59:36Z","timestamp":1663484376000},"page":"1925-1933","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["IL\u20104\/IL\u201013\u2010producing ILC2s are required for timely control of intestinal helminth infection in mice"],"prefix":"10.1002","volume":"52","author":[{"given":"Filipa","family":"Varela","sequence":"first","affiliation":[{"name":"Department of Infection Biology University Hospital Erlangen and Friedrich\u2010Alexander University Erlangen\u2010Nuremberg (FAU)  Erlangen 91054 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Symowski","sequence":"additional","affiliation":[{"name":"Department of Infection Biology University Hospital Erlangen and Friedrich\u2010Alexander University Erlangen\u2010Nuremberg (FAU)  Erlangen 91054 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Pollock","sequence":"additional","affiliation":[{"name":"Department of Infection Biology University Hospital Erlangen and Friedrich\u2010Alexander University Erlangen\u2010Nuremberg (FAU)  Erlangen 91054 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Wirtz","sequence":"additional","affiliation":[{"name":"Department of Medicine 1 University Hospital Erlangen and Friedrich\u2010Alexander University Erlangen\u2010Nuremberg (FAU)  Erlangen 91054 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Voehringer","sequence":"additional","affiliation":[{"name":"Department of Infection Biology University Hospital Erlangen and Friedrich\u2010Alexander University Erlangen\u2010Nuremberg (FAU)  Erlangen 91054 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI34261"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.88"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.2015.53.1.135"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80477-X"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.4049\/jimmunol.140.9.3206","article-title":"The role of L3T4+ and Lyt\u20102+ T cells in the IgE response and immunity to Nippostrongylus brasiliensis","volume":"140","author":"Katona I. M.","year":"1988","journal-title":"J Immunol"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2014.101"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20052448"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08900"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08636"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1003988107"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac9593"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.09.002"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam5809"},{"key":"e_1_2_10_15_1","first-page":"217","article-title":"Tissue\u2010specific pathways extrude activated ILC2s to disseminate type 2 immunity","author":"Ricardo\u2010Gonzalez R. 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