{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:06:54Z","timestamp":1790766414369,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    SARS\u2010CoV\u20102 is a newly emerged coronavirus, causing the global pandemic of respiratory coronavirus disease (COVID\u201019). The type I interferon (IFN) pathway is of particular importance for anti\u2010viral defense and recent studies identified that type I IFNs drive early inflammatory responses to SARS\u2010CoV\u20102. Here, we use a mouse model of SARS\u2010CoV\u20102 infection, facilitating viral entry by intranasal recombinant Adeno\u2010Associated Virus (rAAV) transduction of\n                    <jats:italic>hACE2<\/jats:italic>\n                    in wildtype (WT) and type I IFN receptor\u20101 deficient (\n                    <jats:italic>\n                      Ifnar1\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                      )\n                    <\/jats:italic>\n                    mice, to study the role of type I IFN signalling and innate immune responses during SARS\u2010CoV\u20102 infection. Our data show that type I IFN signalling is essential for inducing anti\u2010viral effector responses to SARS\u2010CoV\u20102, control of virus replication, and to prevent enhanced disease. Furthermore,\n                    <jats:italic>\n                      hACE2\u2010Ifnar1\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    mice had increased gene expression of the chemokine\n                    <jats:italic>Cxcl1<\/jats:italic>\n                    and airway infiltration of neutrophils as well as reduced and delayed production of monocyte\u2010recruiting chemokine CCL2.\n                    <jats:italic>hACE2<\/jats:italic>\n                    \u2010\n                    <jats:italic>\n                      Ifnar1\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    mice showed altered recruitment of inflammatory myeloid cells to the lung upon SARS\u2010CoV\u20102 infection, with a shift from Ly6C\n                    <jats:sup>+<\/jats:sup>\n                    to Ly6C\n                    <jats:sup>\u2013<\/jats:sup>\n                    expressing cells. Together, our findings suggest that type I IFN signalling deficiency results in a dysregulated innate immune response to SARS\u2010CoV\u20102 infection.\n                  <\/jats:p>","DOI":"10.1002\/eji.202249913","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T06:50:18Z","timestamp":1663224618000},"page":"1768-1775","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Type I interferon receptor signalling deficiency results in dysregulated innate immune responses to SARS\u2010CoV\u20102 in mice"],"prefix":"10.1002","volume":"52","author":[{"given":"Patricia P.","family":"Ogger","sequence":"first","affiliation":[{"name":"Section of Respiratory Infections, National Heart and Lung Institute Imperial College London, St Mary's Campus  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minerva","family":"Garcia Mart\u00edn","sequence":"additional","affiliation":[{"name":"Section of Respiratory Infections, National Heart and Lung Institute Imperial College London, St Mary's Campus  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Michalaki","sequence":"additional","affiliation":[{"name":"Section of Respiratory Infections, National Heart and Lung Institute Imperial College London, St Mary's Campus  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Imperial College London, St Mary's Campus  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan C.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Imperial College London, St Mary's Campus  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Du","sequence":"additional","affiliation":[{"name":"Radcliffe Department of Medicine (NDCLS) University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran M.","family":"Miah","sequence":"additional","affiliation":[{"name":"Radcliffe Department of Medicine (NDCLS) University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Habib","sequence":"additional","affiliation":[{"name":"Radcliffe Department of Medicine (NDCLS) University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Hyde","sequence":"additional","affiliation":[{"name":"Radcliffe Department of Medicine (NDCLS) University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah R.","family":"Gill","sequence":"additional","affiliation":[{"name":"Radcliffe Department of Medicine (NDCLS) University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy S.","family":"Barclay","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Imperial College London, St Mary's Campus  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Johansson","sequence":"additional","affiliation":[{"name":"Section of Respiratory Infections, National Heart and Lung Institute Imperial College London, St Mary's Campus  London 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