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One important element of this alarm system is the innate immune system, which recognizes pathogen\u2010\/microbe\u2010 or damage\u2010associated molecular patterns via pattern recognition receptors localized in the cytosol or in membranes of innate immune cells such as macrophages, dendritic cells, and mast cells but also of T cells, B cells, and epithelial cells. Activation of the innate immune system results in inflammation and is a pre\u2010requisite for activation of the adaptive immune system. Another important element is represented by the unfolded protein response (UPR), a stress response of the endoplasmic reticulum. The UPR regulates proteostasis and also contributes to the course of inflammatory diseases such as cancer, diabetes, obesity, and neurodegenerative diseases. In addition, the UPR is instrumental in allergic contact dermatitis. This inflammatory skin disease, affecting 5\u201310% of the population, is caused by T cells recognizing low\u2010molecular weight organic chemicals and metal ions.<\/jats:p>\n                  <jats:p>In this mini\u2010review, we discuss the orchestration of inflammatory responses by the interplay of the innate immune system with cellular stress responses in allergic contact dermatitis, with a focus on the UPR.<\/jats:p>","DOI":"10.1002\/eji.202249984","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T23:08:10Z","timestamp":1680649690000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Endoplasmic reticulum stress and the inflammatory response in allergic contact dermatitis"],"prefix":"10.1002","volume":"53","author":[{"given":"Philipp R.","family":"Esser","sequence":"first","affiliation":[{"name":"Allergy Research Group Department of Dermatology Medical Center \u2013 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