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Two signaling pathways via the preB cell receptor (preBCR) and the interleukin 7 receptor \u03b1 (IL\u20107R\u03b1) chain govern the balance between differentiation and proliferation at this stage and both receptor pathways are routinely altered in human BCP\u2010ALL. Here, we review the immunobiology of both the preBCR as well as the IL\u20107R\u03b1 and analyze the human BCP\u2010ALL spectrum in the light of these signaling complexes. Finally, we present a terminology for preBCR signaling modules that distinguishes a pro\u2010proliferative \u201cphase\u2010I\u201d module from a pro\u2010differentiative \u201cphase\u2010II\u201d module. This terminology might serve as a framework to better address shared oncogenic mechanics of preB cell stage BCP\u2010ALL.<\/jats:p>","DOI":"10.1002\/eji.202250093","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:43Z","timestamp":1676937643000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Puppet masters of B\u2010cell progenitor acute lymphoblastic leukemia: The preB cell receptor and the interleukin 7 receptor \u03b1"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1019-4059","authenticated-orcid":false,"given":"Dennis","family":"Das Gupta","sequence":"first","affiliation":[{"name":"Institute for Medical Microbiology &amp; Hospital Hygiene Philipps University Marburg  Marburg Germany"},{"name":"Medical Department II Hematology and Oncology, University Medical Center Schleswig\u2010Holstein  Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Lohoff","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology &amp; Hospital Hygiene Philipps University Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01620-2"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015850"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)33018-1"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-08-832105"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/243290a0"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1814397115"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2018.1.137"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01557-6"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0315-5"},{"key":"e_1_2_11_11_1","article-title":"The biology of B\u2010progenitor acute lymphoblastic leukemia","volume":"10","author":"Roberts K. 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