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Concanavalin A\u2010induced hepatitis in mice is a well\u2010established model with pathophysiology similar to that of immune\u2010mediated liver injury in human viral and autoimmune hepatitis, and it has been widely used to explore the pathogenesis and clinical treatment of human immune hepatitis. Artemisinin has been shown to exhibit anti\u2010inflammatory effects through unclear mechanisms. In this study, we aimed to assess the effect of the artemisinin derivative TPN10466 on AIH. In vitro studies showed that TPN10466 dose dependently inhibited the percentage of IFN\u2010\u03b3\u2010producing T cells. Further studies showed that TPN10466 attenuated the disease severity of AIH by downregulating the ability of lymphocytes to secrete IFN\u2010\u03b3 and by reducing lymphocyte number in the liver. In addition, we found that TPN10466 treatment reduced T\u2010cell responses by inhibiting JNK, ERK, and p38 pathways. In conclusion, our work suggests that TPN10466 provides protection against the autoimmune disease AIH by suppressing the inflammatory response of T cells, suggesting that TPN10466 may be a promising potential agent for the treatment of AIH.<\/jats:p>","DOI":"10.1002\/eji.202250100","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T15:50:21Z","timestamp":1673970621000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["TPN10466 ameliorates Concanavalin A\u2010induced autoimmune hepatitis in mice via inhibiting ERK\/JNK\/p38 signaling pathway"],"prefix":"10.1002","volume":"53","author":[{"given":"Guangyu","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education Orthopaedic Department of Tongji Hospital School of Life Sciences and Technology Tongji University  Shanghai 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