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Plasmablast and plasma cell subsets, whose primary function is to secrete antibodies, have emerged as important suppressive populations that expand during sepsis. In particular, sepsis supports CD39\n                    <jats:sup>hi<\/jats:sup>\n                    plasmablast metabolic reprogramming associated with adenosine\u2010mediated suppressive activity. Arginine deficiency has been linked to an increased risk of secondary infections in sepsis. Overcoming arginine shortage by citrulline administration efficiently improves sepsis\u2010induced immunosuppression and secondary infections in the cecal ligation and puncture murine model. Here, we aimed to determine the impact of citrulline administration on B cell suppressive responses in sepsis. We demonstrate that restoring arginine bioavailability through citrulline administration markedly reduces the dominant extrafollicular B cell response, decreasing the immunosuppressive LAG3\n                    <jats:sup>+<\/jats:sup>\n                    and CD39\n                    <jats:sup>+<\/jats:sup>\n                    plasma cell populations, and restoring splenic follicles. At the molecular level, the IRF4\/MYC\u2010mediated B cell reprogramming required for extrafollicular plasma cell differentiation is shunted in the splenic B cells of mice fed with citrulline. Our study reveals a prominent impact of nutrition on B cell responses and plasma cell differentiation and further supports the development of citrulline\u2010based clinical studies to prevent sepsis\u2010associated immune dysfunction.\n                  <\/jats:p>","DOI":"10.1002\/eji.202250154","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T23:10:41Z","timestamp":1671837041000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Citrulline enteral administration markedly reduces immunosuppressive extrafollicular plasma cell differentiation in a preclinical model of sepsis"],"prefix":"10.1002","volume":"53","author":[{"given":"Juliette","family":"Gauthier","sequence":"first","affiliation":[{"name":"UMR INSERM S1236, LabEx IGO, Univ Rennes, EFS  Rennes 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