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Bacillus Calmette\u2010Gu\u00e9rin (BCG) provides limited protection in adolescents and adults. To explore the factors reducing efficacy of BCG vaccine, we assess the impacts of interleukin (IL)\u201010 and alarmins S100A8\/A9 on T\u2010cell memory. We found that BCG\u2010induced IL\u201010 inhibited production of S100A8\/A9 in human peripheral blood mononuclear cells (PBMCs) and murine splenocytes. S100A9 deficiency inhibited IFN\u2010\u03b3 production by CD4<jats:sup>+<\/jats:sup> T cells in the early phase of BCG immunization and hindered the development of effector memory T helper type 1 (Th1) cells, while IL\u201010 deficiency promoted Th1 memory and blocking IL\u201010 signaling enhanced Th1 protective recall response against <jats:italic>M.tb<\/jats:italic>. IL\u201010 inhibited the binding of transcription factor CCAAT enhancer binding protein beta to <jats:italic>S100a8\/a9<\/jats:italic> promoter leading to S100A8\/A9 reduction. S100A8\/A9 heterodimer enhanced the IFN\u2010\u03b3 production via receptor for advanced glycation end products signaling in CD4<jats:sup>+<\/jats:sup> T cells. Our results demonstrate a hurdle to development of Th1 memory after BCG immunization and clarify the mechanism of the regulation of Th1 memory by IL\u201010 and S100A8\/A9.<\/jats:p>","DOI":"10.1002\/eji.202250204","type":"journal-article","created":{"date-parts":[[2023,1,22]],"date-time":"2023-01-22T01:19:05Z","timestamp":1674350345000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Bacillus Calmette\u2013Gu\u00e9rin\u2013induced interleukin\u201010 inhibits S100A8\/A9 production and hinders development of T helper type 1 memory in mice"],"prefix":"10.1002","volume":"53","author":[{"given":"Yaping","family":"Wang","sequence":"first","affiliation":[{"name":"Hubei Province Key Laboratory of Allergy and Immunology and Department of Anatomy Wuhan University TaiKang Medical School (School of Basic Medical Sciences)  Wuhan China"},{"name":"Department of Clinical Laboratory Xi'an People's Hospital (Xi'an Fourth 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