{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:09:40Z","timestamp":1772118580769,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,25]],"date-time":"2023-02-25T00:00:00Z","timestamp":1677283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Parasitic nematodes infect more than 1 billion people in the global south. The development of effective antihelminthic vaccines is a crucial tool for their future elimination. Protective immune responses to nematodes depend on Gata3\n                    <jats:sup>+<\/jats:sup>\n                    Th2 cells, which can also be induced by nematode\u2010released products. Whether these nematode products induce antigen\u2010specific long\u2010lived memory T cells and thereby confer protection against a challenge infection is not known yet. Hence, we set out to characterize the formation of memory Th2 cells induced by immunization with\n                    <jats:italic>Heligmosomoides polygyrus<\/jats:italic>\n                    excretory\u2010secretory (HES) products, infection\u2010induced versus immunization\u2010induced recall responses to a challenge infection, and whether HES\u2010induced memory T cells show protective properties following adoptive transfer. Our results show that 8 weeks postimmunization, HES induces long\u2010lived functional memory Th2 cells at the site of immunization in the peritoneal cavity. Following a\n                    <jats:italic>H. polygyrus<\/jats:italic>\n                    challenge infection, HES\u2010immunized mice display MHC\u2010II\u2010dependent antigen\u2010specific Th2 cytokine responses in the gut\u2010draining lymph nodes, comparable to those induced by a prior natural infection. Moreover, adoptive transfer of sorted memory CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells from HES\u2010immunized donors reduces female worm fecundity following a challenge\n                    <jats:italic>H. polygyrus<\/jats:italic>\n                    infection in recipient mice, highlighting a protective role for immunization\u2010induced memory T cells.\n                  <\/jats:p>","DOI":"10.1002\/eji.202250237","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T22:59:34Z","timestamp":1676329174000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Immunization with excretory\u2010secretory molecules of intestinal nematodes induces antigen\u2010specific protective memory Th2 cell responses"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4119-7308","authenticated-orcid":false,"given":"Ivet A.","family":"Yordanova","sequence":"first","affiliation":[{"name":"Institute of Immunology Center for Infection Medicine Freie Universit\u00e4t Berlin, Berlin  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis E.","family":"Elizalde\u2010Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"Institute of Immunology Center for Infection Medicine Freie Universit\u00e4t Berlin, Berlin  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Institute of Immunology Center for Infection Medicine Freie Universit\u00e4t Berlin, Berlin  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(20)30398-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI34261"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2005.00753.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001621"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006481"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2018.07.005"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.2014.872035"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.576748"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939644"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00502-09"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2013.40"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1714731115"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.93"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201646575"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.842870"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-018-0102-8"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1004140"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004676"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003492"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02282"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202170126"}],"container-title":["European 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