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The archetype PCSK, FURIN, promotes the pathogenicity of viruses by proteolytically processing viral proteins. FURIN has also important regulatory functions in both innate and adaptive immune responses but its role in the CD8\n                    <jats:sup>+<\/jats:sup>\n                    CTLs remains enigmatic. We used a T\u2010cell\u2010specific FURIN deletion\n                    <jats:italic>in vivo<\/jats:italic>\n                    to demonstrate that FURIN promotes host response against the CTL\u2010dependent lymphocytic choriomeningitis virus by virtue of restricting viral burden and augmenting interferon gamma (IFNG) production. We also characterized\n                    <jats:italic>Furin<\/jats:italic>\n                    KO CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells\n                    <jats:italic>ex vivo<\/jats:italic>\n                    , including after their activation with FURIN regulating cytokines IL12 or TGFB1.\n                    <jats:italic>Furin<\/jats:italic>\n                    KO CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells show an inherently activated phenotype characterized by the upregulation of effector genes and increased frequencies of CD44\n                    <jats:sup>+<\/jats:sup>\n                    , TNF\n                    <jats:sup>+<\/jats:sup>\n                    , and IFNG\n                    <jats:sup>+<\/jats:sup>\n                    cells. In the activated CTLs, FURIN regulates the productions of IL2, TNF, and GZMB and the genes associated with the TGFBR\u2010signaling pathway. FURIN also controls the expression of\n                    <jats:italic>Eomes<\/jats:italic>\n                    ,\n                    <jats:italic>Foxo1<\/jats:italic>\n                    , and\n                    <jats:italic>Bcl6<\/jats:italic>\n                    and the levels of ITGAE and CD62L, which implies a role in the development of CTL memory. Collectively, our data suggest that the T\u2010cell expressed FURIN is important for host responses in viral infections, CTL homeostasis\/activation, and memory development.\n                  <\/jats:p>","DOI":"10.1002\/eji.202250246","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T16:29:29Z","timestamp":1680625769000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["FURIN regulates cytotoxic T\u2010lymphocyte effector function and memory cell transition in mice"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6623-844X","authenticated-orcid":false,"given":"Markus J.T.","family":"Ojanen","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Technology Tampere University  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda 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