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Pulmonary sarcoidosis (PS) shares a number of clinical, radiological, and histopathological characteristics with that of pulmonary tuberculosis (PTB). Due to this, clinicians face issues in differentiating between PS and PTB in a substantial number of cases. There is a lack of any specific biomarker that can diagnose PS distinctively from PTB. We compared T\u2010cell\u2010based signature cytokines in patients with PS and PTB. In this study, we proposed a serum biomarker panel consisting of cytokines from cells: T helper (Th) 1 [interferon\u2010gamma (IFN\u2010\u03b3); tumor necrosis factor\u2010alpha (TNF\u2010\u03b1)], Th9 [interleukin (IL)\u20109], Th17 [IL\u201017], and T regulatory (Treg) [IL\u201010; transforming growth factor\u2010beta (TGF\u2010\u03b2)]. We performed the principal component analysis that demonstrated that our serum cytokine panel has a significant predictive ability to differentiate PS from PTB. Our results could aid clinicians to improve the diagnostic workflow for patients with PS in TB endemic settings where the diagnosis between PS and PTB is often ambiguous.<\/jats:p>","DOI":"10.1002\/eji.202250255","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T10:52:31Z","timestamp":1690541551000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["T\u2010cell signature cytokines distinguish pulmonary sarcoidosis from pulmonary tuberculosis"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6258-2160","authenticated-orcid":false,"given":"Rashi","family":"Jain","sequence":"first","affiliation":[{"name":"Department of Pulmonary Critical Care and Sleep Medicine All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinkee","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Transplant Immunology and Immunogenetics All India Institute of Medical Sciences New Delhi India"},{"name":"Rutgers Cancer Institute of New Jersey New Brunswick NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushmita","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Department of Transplant Immunology and Immunogenetics All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipendra K.","family":"Mitra","sequence":"additional","affiliation":[{"name":"Department of Transplant Immunology and Immunogenetics All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anant","family":"Mohan","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Critical Care and Sleep Medicine All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Hadda","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Critical Care and Sleep Medicine All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karan","family":"Madan","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Critical Care and Sleep Medicine All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randeep","family":"Guleria","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Critical Care and Sleep Medicine All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-015-8477-8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpmed.2016.03.009"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/20734735.0207-2020"},{"key":"e_1_2_11_5_1","first-page":"23","volume-title":"Sarcoidosis","author":"Newman L. 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