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Current knowledge about LCs mainly originates from studies utilizing mouse models, whereas with the development of single\u2010cell techniques, there has been significant progress for human LCs, which has updated our understanding of the phenotype, ontogeny, differentiation regulation, and function of LCs. In this review, we delineated the progress of human LCs and summarized LCs\u2019 function in inflammatory skin diseases, providing new ideas for precise regulation of LC function in the prevention and treatment of skin diseases.<\/jats:p>","DOI":"10.1002\/eji.202250280","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:25:02Z","timestamp":1721348702000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Langerhans cells and skin immune diseases"],"prefix":"10.1002","author":[{"given":"Ronghui","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Dermatology Shanghai Institute of Dermatology Huashan Hospital Fudan University  Shanghai P. R. China"},{"name":"Department of Dermatology Wuhan No. 1 Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan P. R. China"},{"name":"Hubei Province &amp; Key Laboratory of Skin Infection and Immunity  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Allergy and Rheumatology Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs Hospital for Skin Diseases Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College  Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shanghai Institute of Dermatology Huashan Hospital Fudan University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41577-018-0084-5","article-title":"The immunological anatomy of the skin","volume":"19","author":"Kabashima K.","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1038\/s41590-018-0256-2","article-title":"The epithelial immune microenvironment (EIME) in atopic dermatitis and psoriasis","volume":"19","author":"Dainichi T.","year":"2018","journal-title":"Nat. Immunol."},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.3389\/fimmu.2017.01941","article-title":"Redefining the role of Langerhans cells as immune regulators within the skin","volume":"8","author":"West H. 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