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The overall pathogenesis of vitiligo remains to be elucidated. Nevertheless, considerable research indicates that adaptive immune activation plays a key role in this process. Specifically, the interferon\u2010gamma (IFN\u2010\u03b3), C\u2010X\u2010C motif chemokine ligands (CXCL9\/10), and C\u2010X\u2010C motif chemokine receptor (CXCR3) signaling axis, collectively referred to as IFN\u2010\u03b3\u2010CXCL9\/10\u2010CXCR3 or ICC axis, has emerged as a key mediator responsible for the recruitment of autoimmune CXCR3\n                    <jats:sup>+<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. These cells serve as executioners of melanocytes by promoting their detachment and apoptosis. Moreover, IFN\u2010\u03b3 is generated by activated T cells to create a positive feedback loop, exacerbating the autoimmune response. This review not only delves into the mechanistic insights of the ICC axis but also explores the significant immunological effects of associated cytokines and their receptors. Additionally, the review provides a thorough comparison of existing and emerging treatment options that target the ICC axis for managing vitiligo. This review aims to foster further advancements in basic research within related fields and facilitate a deeper understanding of alternative treatment strategies targeting different elements of the axis.\n                  <\/jats:p>","DOI":"10.1002\/eji.202250281","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T07:50:11Z","timestamp":1699429811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["The IFN\u2010\u03b3\u2010CXCL9\/CXCL10\u2010CXCR3 axis in vitiligo: Pathological mechanism and treatment"],"prefix":"10.1002","volume":"54","author":[{"given":"Hanqing","family":"Liu","sequence":"first","affiliation":[{"name":"Precision Research Center for Refractory Diseases Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"},{"name":"College of Health Science and Technology Shanghai Jiao Tong University School of Medicine  Shanghai P. 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