{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:38:06Z","timestamp":1787013486171,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,14]],"date-time":"2023-05-14T00:00:00Z","timestamp":1684022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI137746"],"award-info":[{"award-number":["AI137746"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI161307"],"award-info":[{"award-number":["AI161307"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Systemic Lupus Erythematosus (SLE) is characterized by pathogenic autoantibodies against nucleic acid\u2010containing antigens. Understanding which B\u2010cell subsets give rise to these autoantibodies may reveal therapeutic approaches for SLE that spare protective responses. Mice lacking the tyrosine kinase Lyn, which limits B and myeloid cell activation, develop lupus\u2010like autoimmune diseases characterized by increased autoreactive plasma cells (PCs). We used a fate\u2010mapping strategy to determine the contribution of T\u2010bet\n                    <jats:sup>+<\/jats:sup>\n                    B cells, a subset thought to be pathogenic in lupus, to the accumulation of PCs and autoantibodies in Lyn\n                    <jats:sup>\u2010\/\u2010<\/jats:sup>\n                    mice. Approximately, 50% of splenic PCs in Lyn\n                    <jats:sup>\u2010\/\u2010<\/jats:sup>\n                    mice originated from T\u2010bet\n                    <jats:sup>+<\/jats:sup>\n                    cells, a significant increase compared to WT mice. In vitro, splenic PCs derived from T\u2010bet\n                    <jats:sup>+<\/jats:sup>\n                    B cells secreted both IgM and IgG anti\u2010dsDNA antibodies. To determine the role of these cells in autoantibody production\n                    <jats:italic>in vivo<\/jats:italic>\n                    , we prevented T\u2010bet\n                    <jats:sup>+<\/jats:sup>\n                    B cells from differentiating into PCs or class switching in Lyn\n                    <jats:sup>\u2010\/\u2010<\/jats:sup>\n                    mice. This resulted in a partial reduction in splenic PCs and anti\u2010dsDNA IgM and complete abrogation of anti\u2010dsDNA IgG. Thus, T\u2010bet\n                    <jats:sup>+<\/jats:sup>\n                    B cells make an important contribution to the autoreactive PC pool in Lyn\n                    <jats:sup>\u2010\/\u2010<\/jats:sup>\n                    mice.\n                  <\/jats:p>","DOI":"10.1002\/eji.202250300","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T17:09:40Z","timestamp":1683133780000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["T\u2010bet\u2010expressing B cells contribute to the autoreactive plasma cell pool in Lyn\n                    <sup>\u2010\/\u2010<\/sup>\n                    mice"],"prefix":"10.1002","volume":"53","author":[{"given":"Kristina","family":"Ottens","sequence":"first","affiliation":[{"name":"Department of Internal Medicine UT Southwestern Medical Center  Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jalyn","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine UT Southwestern Medical Center  Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne B.","family":"Satterthwaite","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine UT Southwestern Medical Center  Dallas TX USA"},{"name":"Department of Immunology UT Southwestern Medical Center  Dallas TX 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