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Neutrophils can regulate inflammatory and immune responses through degranulation, reactive oxygen species generation, the production of cytokines and chemokines, and NETosis. Emerging evidence has indicated that neutrophils contribute to the pathogenesis of various noncancer liver diseases, including nonalcoholic fatty liver disease, alcohol\u2010associated liver disease, hepatic ischemia\u2012reperfusion injury, and liver fibrosis. Cellular interactions among neutrophils, other immune cells, and nonimmune cells constitute a complex network that regulates the immune microenvironment of the liver. This review summarizes novel neutrophil subtypes, including CD177+ neutrophils and low\u2010density neutrophils. Moreover, we provide an overview of the cellular cros stalk of neutrophils in noncancer liver diseases, aiming to shed new light on mechanistic studies of novel neutrophil subtypes. In addition, we discuss the potential of neutrophils as therapeutic targets in noncancer liver diseases, including inhibitors targeting NETosis, granule proteins, and chemokines.<\/jats:p>","DOI":"10.1002\/eji.202250324","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T23:05:49Z","timestamp":1690412749000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Neutrophil subsets in noncancer liver diseases: Cellular crosstalk and therapeutic targets"],"prefix":"10.1002","volume":"53","author":[{"given":"Chen","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology and Sichuan University\u2010University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer West China Hospital Sichuan University  Chengdu 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