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Other natural skin lipids inhibit CD1a\u2010mediated T\u2010cell responses, providing an entry point for the development of therapeutic lipids that block T\u2010cell responses. Increasing evidence points to a distinct role of CD1a in type 2 and 22 T\u2010cell responses, providing new insights into psoriasis, contact dermatitis, and other T\u2010cell\u2010mediated skin diseases.<\/jats:p>","DOI":"10.1002\/eji.202250333","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T10:25:03Z","timestamp":1691144703000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["CD1a and bound lipids drive T\u2010cell responses in human skin disease"],"prefix":"10.1002","volume":"53","author":[{"given":"Graham S.","family":"Ogg","sequence":"first","affiliation":[{"name":"Medical Research Council Human Immunology Unit MRC Weatherall Institute of Molecular Medicine University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie","family":"Rossjohn","sequence":"additional","affiliation":[{"name":"Infection and Immunity Program and Department of Biochemistry and Molecular Biology Biomedicine Discovery Institute Monash University  Clayton Victoria Australia"},{"name":"Institute of Infection and Immunity Cardiff University School of Medicine  Heath Park Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachael A.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Dermatology Brigham and Women's Hospital Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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