{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T06:11:47Z","timestamp":1792303907313,"version":"4.4.0"},"reference-count":101,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T00:00:00Z","timestamp":1694908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0509400"],"award-info":[{"award-number":["2020YFA0509400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0110300"],"award-info":[{"award-number":["2019YFA0110300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82150117"],"award-info":[{"award-number":["82150117"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071745"],"award-info":[{"award-number":["82071745"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32300760"],"award-info":[{"award-number":["32300760"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Signal regulatory protein alpha (SIRP\u03b1) is a crucial inhibitory regulator expressed on the surface of myeloid cells, including macrophages, dendritic cells, monocytes, neutrophils, and microglia. SIRP\u03b1 plays an indispensable role in innate immune and adoptive immune responses in cancer immunology, tissue homeostasis, and other physiological or phycological conditions. This review provides an overview of the research history, ligands, signal transduction pathways, and functional mechanisms associated with SIRP\u03b1. Additionally, we summarize the therapeutic implications of targeting SIRP\u03b1 as a promising novel strategy in immuno\u2010oncology.<\/jats:p>","DOI":"10.1002\/eji.202350375","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T12:44:14Z","timestamp":1694004254000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["SIRP\u03b1: A key player in innate immunity"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8753-2987","authenticated-orcid":false,"given":"Yongyi","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Immunology and Microbiology Zhongshan School of Medicine Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunliu","family":"Huang","sequence":"additional","affiliation":[{"name":"Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat\u2010sen University  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzhao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology Zhongshan School of Medicine Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Engineering &amp; Technology Research Center for Disease\u2010Model Animals Laboratory Animal Center, Zhongshan School of Medicine, Sun Yat\u2010sen University  Guangzhou China"},{"name":"Key Laboratory of Tropical Disease Control of the Ministry of Education Sun Yat\u2010sen University  Guangzhou China"},{"name":"Jinfeng Laboratory  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a122686"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3440667"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.44.27652"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-22-08702.1997"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.16.12.6887"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.35.22719"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.21.13223"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.2.559"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(2000)30:8<2130::AID-IMMU2130>3.0.CO;2-8"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002334200"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(00)01906-1"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-1896"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1859"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2008.12.001"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.1.9"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.12.7781"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.4.2562"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.11.7741"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-019-0177-0"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2008.05.026"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.550558"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M701565200"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e04-10-0918"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.739048"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200711-1661OC"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.324533"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00758-X"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.622598"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.12.005"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.01.004"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200708043"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.4.2004"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.05.046"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.08.021"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.05.045"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20120502"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13548"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001375"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22076"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.110111"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.07.008"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0183-z"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-017-0004-z"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23710"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1677\/JME-08-0021"},{"key":"e_1_2_10_47_1","first-page":"865","article-title":"Induction of \u03b2\u2010catenin by the suppression of signal regulatory protein \u03b11 in K562 cells","volume":"27","author":"Maekawa T.","year":"2011","journal-title":"Int. J. Mol. Med."},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2013.06.005"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01744"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.593219"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1721434116"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3931"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12527"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.11.5832"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-0037-T"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.4.2427"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2013.02.009"},{"key":"e_1_2_10_58_1","first-page":"218","article-title":"The SIRP\u03b1\u2010CD47 immune checkpoint in NK cells","author":"Deuse T.","year":"2021","journal-title":"J. Exp. Med."},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401984"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0236"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0216-7"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609661104"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-440354"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019002194"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1527"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aam6202"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/gtc.12238"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15497"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02710"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2012.08682.x"},{"key":"e_1_2_10_71_1","article-title":"Signal regulatory protein \u03b1 protects podocytes through promoting autophagic activity","volume":"5","author":"Li L.","year":"2019","journal-title":"JCI Insight"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1159\/000464388"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201948410"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.10.018"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-015-8729-y"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000137"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009662"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab369"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-022-00023-x"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12766"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2005"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2014.04.016"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13236"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00876"},{"key":"e_1_2_10_85_1","first-page":"E22","article-title":"Role of SIRP\u03b1 in homeostatic regulation of T cells and fibroblastic reticular cells in the spleen","volume":"63","author":"Respatika D.","year":"2017","journal-title":"Kobe J. Med. Sci."},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1710877114"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.134728"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2019-3239"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI135528"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23442-z"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-124876"},{"key":"e_1_2_10_92_1","unstructured":"Ingelheim B. BI 765063 and BI 770371: SIRP\u03b1 antagonists 2023."},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2021-147292"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1807315"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.02018"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/jha2.687"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2200157"},{"key":"e_1_2_10_98_1","unstructured":"ClinicalTrials.gov A study of DS\u20101103a combination therapy in participants with advanced solid tumors 2023."},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-019-0772-0"},{"key":"e_1_2_10_100_1","first-page":"11","article-title":"BYON4228 is a pan\u2010allelic antagonistic SIRP\u03b1 antibody that potentiates destruction of antibody\u2010opsonized tumor cells and lacks binding to SIRP\u03b3 on T cells","author":"Helden M. J.","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-020-00989-w"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01385-2"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.202350375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T05:20:12Z","timestamp":1698816012000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.202350375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,17]]},"references-count":101,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/eji.202350375"],"URL":"https:\/\/doi.org\/10.1002\/eji.202350375","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/EJI.202350375\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202350375\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202350375\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202350375\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202350375\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202350375\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202350375\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202350375\/v1\/review1","asserted-by":"object"}]},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,17]]},"assertion":[{"value":"2023-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2350375"}}