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Optimal activation of NLRP3 inflammasome is crucial for host defense against pathogens and the maintenance of immune homeostasis. Aberrant NLRP3 inflammasome activity has been implicated in various inflammatory diseases. Posttranslational modifications (PTMs) of NLRP3, a key inflammasome sensor, play critical roles in directing inflammasome activation and controlling the severity of inflammation and inflammatory diseases, such as arthritis, peritonitis, inflammatory bowel disease, atherosclerosis, and Parkinson's disease. Various NLRP3 PTMs, including phosphorylation, ubiquitination, and SUMOylation, could direct inflammasome activation and control inflammation severity by affecting the protein stability, ATPase activity, subcellular localization, and oligomerization of NLRP3 as well as the association between NLRP3 and other inflammasome components. Here, we provide an overview of the PTMs of NLRP3 and their roles in controlling inflammation and summarize potential anti\u2010inflammatory drugs targeting NLRP3 PTMs.<\/jats:p>","DOI":"10.1002\/eji.202350382","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T06:44:17Z","timestamp":1688021057000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Posttranslational modifications of NLRP3 and their regulatory roles in inflammasome activation"],"prefix":"10.1002","volume":"53","author":[{"given":"Ying","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Pathogenic Biology and Key Laboratory of Infection and Immunity of Shandong Province School of Basic Medical Science Cheeloo College of Medicine Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8440-2274","authenticated-orcid":false,"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology and Key Laboratory of Infection and Immunity of Shandong Province School of Basic Medical Science Cheeloo College of Medicine Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0165-0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.11.011"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04467-w"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2121353119"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05570-8"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00211"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.58"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0215-7"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-00886-5"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12285"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-022-00922-w"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2016.29"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.618231"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02305"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI83669"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806963106"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26142-w"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-020-00832-5"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3538"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.09.008"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20162040"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.08.017"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201656"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201949666"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2000649"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160933"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-020-0510-3"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168780"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13727"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2021.10.012"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.11592"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.645549"},{"key":"e_1_2_6_34_1","first-page":"326","article-title":"PARK2 attenuates house dust mite\u2010induced inflammatory reaction, pyroptosis and barrier dysfunction in BEAS\u20102B cells by ubiquitinating NLRP3","volume":"13","author":"Ge X.","year":"2021","journal-title":"Am. 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