{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T12:36:19Z","timestamp":1782909379592,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Reexposure to a pathogen triggers the activation of memory T cells that have already encountered a similar microbe. These long\u2010lived CD4 T cells either circulate through the blood and tissues or reside within organs and are referred to as tissue\u2010resident T cells (CD4 T\n                    <jats:sub>RM<\/jats:sub>\n                    ). In the current issue of the\n                    <jats:italic>European Journal of Immunology<\/jats:italic>\n                    [Eur. J. Immunol. 2023. 53: 2250247] issue, Curham et\u00a0al. found that tissue\u2010resident memory CD4 T cells in the lung and nasal tissues can respond to noncognate immune challenges. CD4 T\n                    <jats:sub>RM<\/jats:sub>\n                    cells, which were formed in response to\n                    <jats:italic>Bordetella pertussis<\/jats:italic>\n                    , proliferated and produced IL\u201017A in response to a secondary challenge with heat\u2010killed\n                    <jats:italic>Klebsiella pneumonia<\/jats:italic>\n                    or lipopolysaccharide (LPS). This bystander response depends on the presence of dendritic cells that provide inflammatory cytokines. Furthermore, post\n                    <jats:italic>K. pneumonia<\/jats:italic>\n                    , intranasal immunization with whole cell pertussis vaccine reduced bacterial burden in the nasal tissue in a CD4 T\u2010cell\u2010dependent manner. The study indicates that the noncognate activation of T\n                    <jats:sub>RM<\/jats:sub>\n                    may serve as an innate\u2010like immune response that rapidly develops before establishing a new pathogen\u2010specific adaptive immune response.\n                  <\/jats:p>","DOI":"10.1002\/eji.202350413","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T20:33:25Z","timestamp":1678480405000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Bystander activation of tissue\u2010resident memory CD4 T cells: Getting by with a little help from unfamiliar T\u2010cell friends"],"prefix":"10.1002","volume":"53","author":[{"given":"Rebecca","family":"Cornelis","sequence":"first","affiliation":[{"name":"Department of Systems Immunology Weizmann Institute of Science  Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9604-212X","authenticated-orcid":false,"given":"Ziv","family":"Shulman","sequence":"additional","affiliation":[{"name":"Department of Systems Immunology Weizmann Institute of Science  Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,22]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201733"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abo5871"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.66"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400019"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2017.43"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2612"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0607-7"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abc4557"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-00985-3"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-020-00486-7"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines8040729"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202250247"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-021-00407-5"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abb6808"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-019-0218-5"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.85832"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.add3075"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.202350413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/eji.202350413","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.202350413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T16:35:44Z","timestamp":1692462944000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.202350413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,22]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1002\/eji.202350413"],"URL":"https:\/\/doi.org\/10.1002\/eji.202350413","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/EJI.202350413\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202350413\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202350413\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,22]]},"assertion":[{"value":"2023-02-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2350413"}}