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Radical S\u2010adenosyl methionine domain containing 2 (RSAD2) is a viral suppressor protein regulated by type I IFN, and it has been proven to play an important regulatory role in SLE. However, the mechanism by which RSAD2 participates in the pathogenesis of SLE is unclear. In this study, we observed higher expression levels of RSAD2 in CD4<jats:sup>+<\/jats:sup> T\u2010cell subsets from the peripheral blood of SLE patients than in those from healthy controls by bioinformatics analysis and validation experiments. We analyzed the expression of RSAD2 in CD4<jats:sup>+<\/jats:sup> T cells of patients with SLE and other autoimmune diseases. In addition, we found that the expression of RSAD2 in CD4<jats:sup>+<\/jats:sup> T cells might be regulated by IFN\u2010\u03b1, and RSAD2 significantly affected the differentiation of Th17 cells and T follicular helper (Tfh) cells. Our findings underlined that RSAD2 may promote B\u2010cell activation by promoting the differentiation of Th17 and Tfh cells in SLE patients, a process that is regulated by IFN\u2010\u03b1.<\/jats:p>","DOI":"10.1002\/eji.202350420","type":"journal-article","created":{"date-parts":[[2023,5,14]],"date-time":"2023-05-14T05:04:57Z","timestamp":1684040697000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Interferon\u2010\u03b1 regulates abnormally increased expression of RSAD2 in Th17 and Tfh cells in systemic lupus erythematosus patients"],"prefix":"10.1002","volume":"53","author":[{"given":"Yue","family":"Xin","sequence":"first","affiliation":[{"name":"Department of Dermatology Second Xiangya Hospital Hunan Key Laboratory of Medical Epigenomics Central South University  Hunan 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