{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:43:25Z","timestamp":1791240205591,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,23]],"date-time":"2023-07-23T00:00:00Z","timestamp":1690070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Alveolar macrophages (alvMs) play an important role for maintenance of lung function by constant removal of cellular debris in the alveolar space. They further contribute to defense against microbial or viral infections and limit tissue damage during acute lung injury. alvMs arise from embryonic progenitor cells, seed the alveoli before birth, and have life\u2010long self\u2010renewing capacity. However, recruited monocytes may also help to restore the alvM population after depletion caused by toxins or influenza virus infection. At present, the population dynamics and cellular plasticity of alvMs during allergic lung inflammation is poorly defined. To address this point, we used a mouse model of\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    \u2010induced allergic lung inflammation and observed that Th2\u2010derived IL\u20104 and IL\u201013 caused almost complete disappearance of alvMs. This effect required STAT6 expression in alvMs and also occurred in various other settings of type 2 immunity\u2010mediated lung inflammation or administration of IL\u20104 complexes to the lung. In addition, Th2 cells promoted conversion of alvMs to alternatively activated macrophages and multinucleated giant cells. Given the well\u2010established role of alvMs for maintenance of lung function, this process may have implications for resolution of inflammation and tissue homeostasis in allergic asthma.\n                  <\/jats:p>","DOI":"10.1002\/eji.202350475","type":"journal-article","created":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T04:28:12Z","timestamp":1689395292000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Th2\u2010dependent disappearance and phenotypic conversion of mouse alveolar macrophages"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0598-9714","authenticated-orcid":false,"given":"Axel","family":"Dietschmann","sequence":"first","affiliation":[{"name":"Department of Infection Biology University Hospital Erlangen and Friedrich\u2010Alexander Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU) Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8998-8542","authenticated-orcid":false,"given":"Andreas","family":"Ruhl","sequence":"additional","affiliation":[{"name":"Department of Infection Biology University Hospital Erlangen and Friedrich\u2010Alexander Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU) Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Murray","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Biochemistry Martinsried Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"G\u00fcnther","sequence":"additional","affiliation":[{"name":"Department of Medicine 1 Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU) Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Medicine 1 Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU) Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padraic","family":"Fallon","sequence":"additional","affiliation":[{"name":"Trinity Biomedical Sciences Institute School of Medicine Trinity College Dublin Dublin Ireland"},{"name":"Trinity Translational Medicine Institute School of Medicine Trinity College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6650-0639","authenticated-orcid":false,"given":"David","family":"Voehringer","sequence":"additional","affiliation":[{"name":"Department of Infection Biology University Hospital Erlangen and Friedrich\u2010Alexander Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU) Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.12.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.04.004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.583042"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210745"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.10.007"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01777"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2020.08.008"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.6.3034-3042.2003"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.2.891-903.2003"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004053"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abj5761"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-017-0681-6"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.004"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2018.11.001"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-017-0714-1"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201948411"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14318"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2021.100995"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-020-02251-w"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3073"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-02-271981"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201847555"},{"key":"e_1_2_9_24_1","article-title":"Using eggs from Schistosoma mansoni as an in vivo model of helminth\u2010induced lung inflammation","author":"Joyce K. 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