{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:18:19Z","timestamp":1791919099867,"version":"4.3.4"},"reference-count":145,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The CNS has traditionally been considered an immune\u2010privileged organ, but recent studies have identified a plethora of immune cells in the choroid plexus, meninges, perivascular spaces, and cribriform plate. Although those immune cells are crucial for the maintenance of CNS homeostasis and for neural protection against infections, they can lead to neuroinflammation in some circumstances. The blood and the lymphatic vasculatures exhibit distinct structural and molecular features depending on their location in the CNS, greatly influencing the compartmentalization and the nature of CNS immune responses. In this review, we discuss how endothelial cells regulate the migration and the functions of T cells in the CNS both at steady\u2010state and in murine models of neuroinflammation, with a special focus on the anatomical, cellular, and molecular mechanisms implicated in EAE.<\/jats:p>","DOI":"10.1002\/eji.202350482","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T15:04:39Z","timestamp":1707491079000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Regulation of autoimmune\u2010mediated neuroinflammation by endothelial cells"],"prefix":"10.1002","volume":"54","author":[{"given":"Neil","family":"Kallal","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology Geneva Medical School  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Hugues","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology Geneva Medical School  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Garnier","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology Geneva Medical School  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3666"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2015.08.006"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.10.018"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-8118-8-4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2018.04.003"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay0479"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0824-5"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3871"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.20.081701.141316"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120227"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400401"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2015.08.004"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2012.03.006"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2013.04.006"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-20-0784"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.12.001"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000971"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.01.005"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20092465"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20092642"},{"key":"e_1_2_6_22_1","first-page":"3","article-title":"Lymph node stromal cells constrain immunity via MHC class II self\u2010antigen presentation","author":"Baptista A. P.","year":"2014","journal-title":"eLife"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.201800164"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20132000"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201776"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.03.007"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1708"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043453414"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1530\/VB-19-0033"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.6.1092"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202149238"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu045"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201445125"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.253880"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200212)32:12<3598::AID-IMMU3598>3.0.CO;2-6"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.805657"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.11.8053"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31818f9ca8"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.2.1000"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044397"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep01687"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1614336114"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11337"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20102010"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08478"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070064"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1197"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2012.07.004"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00153-2"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61349-9"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.07.025"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101409"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab094"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.07.007"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.02.009"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww270"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205015666180801111033"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-48538-x"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006585"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0324-9"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2015.129"},{"key":"e_1_2_6_62_1","first-page":"5","article-title":"Internalization and presentation of myelin antigens by the brain endothelium guides antigen\u2010specific T cell migration","author":"Lopes Pinheiro M. A.","year":"2016","journal-title":"eLife"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-38703-2"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abl5162"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202255328"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909142106"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.06.015"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-009-0177-0"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2015.07.027"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1807-1"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3391"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aav0492"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004410051287"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-023-00441-4"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1716"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/10.5.703"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300931"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1433000100"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.003"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1714948115"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1276-4"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040443"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0006-15.2015"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.08.017"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-018-0120-7"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-018-0102-9"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8967"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.06.008"},{"key":"e_1_2_6_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4022"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adc8810"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13066"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13469"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abo7649"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01108-3"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.01.011"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.12.040"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0393-4"},{"key":"e_1_2_6_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3182"},{"key":"e_1_2_6_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0964-2"},{"key":"e_1_2_6_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14432"},{"key":"e_1_2_6_101_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf7844"},{"key":"e_1_2_6_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0213-2"},{"key":"e_1_2_6_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01029-1"},{"key":"e_1_2_6_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01060-2"},{"key":"e_1_2_6_105_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab388"},{"key":"e_1_2_6_106_1","first-page":"6","article-title":"Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI","author":"Absinta M.","year":"2017","journal-title":"eLife"},{"key":"e_1_2_6_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1419-5"},{"key":"e_1_2_6_108_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20142290"},{"key":"e_1_2_6_109_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20170391"},{"key":"e_1_2_6_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0227-9"},{"key":"e_1_2_6_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12568-w"},{"key":"e_1_2_6_112_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.655052"},{"key":"e_1_2_6_113_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190351"},{"key":"e_1_2_6_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-08163-0"},{"key":"e_1_2_6_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01484-6"},{"key":"e_1_2_6_116_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.683676"},{"key":"e_1_2_6_117_1","doi-asserted-by":"publisher","DOI":"10.1369\/0022155412462975"},{"key":"e_1_2_6_118_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abq0375"},{"key":"e_1_2_6_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-021-00880-y"},{"key":"e_1_2_6_120_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.7.4648"},{"key":"e_1_2_6_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199708)182:4<457::AID-PATH870>3.0.CO;2-Y"},{"key":"e_1_2_6_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2476"},{"key":"e_1_2_6_123_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.639140"},{"key":"e_1_2_6_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0368-8"},{"key":"e_1_2_6_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03489-0"},{"key":"e_1_2_6_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12656"},{"key":"e_1_2_6_127_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abe4601"},{"key":"e_1_2_6_128_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1525466113"},{"key":"e_1_2_6_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1895-7"},{"key":"e_1_2_6_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1362-5"},{"key":"e_1_2_6_131_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt259"},{"key":"e_1_2_6_132_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aau8380"},{"key":"e_1_2_6_133_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201303376"},{"key":"e_1_2_6_134_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.12.4585.bloodjournal88124585"},{"key":"e_1_2_6_135_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0883-2"},{"key":"e_1_2_6_136_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.4.1940"},{"key":"e_1_2_6_137_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.12.8470"},{"key":"e_1_2_6_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16939"},{"key":"e_1_2_6_139_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-015-0516-2"},{"key":"e_1_2_6_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.10.004"},{"key":"e_1_2_6_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12808"},{"key":"e_1_2_6_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.07.004"},{"key":"e_1_2_6_143_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1993.tb00476.x"},{"key":"e_1_2_6_144_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8454-2-6"},{"key":"e_1_2_6_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04427-4"},{"key":"e_1_2_6_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.09.002"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.202350482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T14:44:44Z","timestamp":1719931484000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.202350482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,9]]},"references-count":145,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/eji.202350482"],"URL":"https:\/\/doi.org\/10.1002\/eji.202350482","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/EJI.202350482\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202350482\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202350482\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202350482\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202350482\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202350482\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202350482\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202350482\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/EJI.202350482\/v1\/review1","asserted-by":"object"}]},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,9]]},"assertion":[{"value":"2023-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2350482"}}